ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Application of nanoscale polymer colloid carriers for targeted delivery of the brain-derived neurotrophic factor through the blood-brain barrier in experimental parkinsonism
About authors
1 Faculty of Medicine and Health Sciences, University Malaysia Sarawak (UNIMAS), Kota Samarahan, Sarawak, Malaysia
2 Department for Expertise of Medicinal Products safety, Scientific Centre for Expert Evaluation of Medicinal Products, Moscow
3 Faculty of Medicine, University Teknologi MARA, Sungai Buloh, Selangor, Malaysia
4 Department of Operative Surgery and Topographic Anatomy, Sechenov First Moscow State Medical University, Moscow
Correspondence should be addressed: Renad N. Alayutdin
1 Volokolamskiy Proezd 10, bl. 4, Moscow, 119876; ur.liam@nudtuayla
About paper
Funding: this work was supported by the grant 600-RMI/RAGS 5/3 (92/2013) of the Universiti Teknologi MARA (UiTM), Selangor, Malaysia.
Received: 2018-07-09
Accepted: 2018-08-20
Published online: 2018-12-23
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Fig. 1. Open field test results in experimental and control mice with modelled parkinsonism (m ± SEM). * — p < 0.05 compared to the 1st group, ** — p < 0.01 compared to the 1st group, & — p < 0.05 compared to the 2nd group, && — p < 0.01 compared to the 2nd group, # — p < 0.05 compared to the 3rd group, ## — p < 0.01 compared to the 3rd group
Fig. 2. Body length and pace in the experimental and control mice with modelled parkinsonism, mm (m ± SEM). * — p < 0.05 compared to the 1st group, ** — p < 0.01
compared to the 1st group, & — p < 0.05 compared to the 2nd group, && — p < 0.01 compared to the 2nd group, # — p < 0.05 compared to the 3rd group, ## — p < 0.01
compared to the 3rd group
Fig. 3. Tremor and duration of rotation in rota-rod (sec) in experimental and control mice with modelled parkinsonism (m ± SEM). * — p < 0.05 compared to the 1st
group, ** — p < 0.01 compared to the 1st group, & — p < 0.05 compared to the 2nd group, && — p < 0.01 compared to the 2nd group, # — p < 0.05 compared to the 3rd group, ## — p < 0.01 compared to the 3rd group
Table 1. Concentration of BDNF in the brain tissue of mice with modelled parkinsonism after treatment with normal saline and BDNF preparations, pg/mg (m+/–SE)
Note: * — p < 0.05 compared to normal saline; ** — p < 0.01 compared to normal saline; ## — р < 0.01 compared to BDNF; & — p < 0.05 compared to nanoparticulate BDNF.
