ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
Copyright: © 2018 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
ORIGINAL RESEARCH
Application of nanoscale polymer colloid carriers for targeted delivery of the brain-derived neurotrophic factor through the blood-brain barrier in experimental parkinsonism
About authors
1 Faculty of Medicine and Health Sciences, University Malaysia Sarawak (UNIMAS), Kota Samarahan, Sarawak, Malaysia
2 Department for Expertise of Medicinal Products safety, Scientific Centre for Expert Evaluation of Medicinal Products, Moscow
3 Faculty of Medicine, University Teknologi MARA, Sungai Buloh, Selangor, Malaysia
4 Department of Operative Surgery and Topographic Anatomy, Sechenov First Moscow State Medical University, Moscow
Correspondence should be addressed: Renad N. Alayutdin
1 Volokolamskiy Proezd 10, bl. 4, Moscow, 119876; ur.liam@nudtuayla
About paper
Funding: this work was supported by the grant 600-RMI/RAGS 5/3 (92/2013) of the Universiti Teknologi MARA (UiTM), Selangor, Malaysia.
Received: 2018-07-09
Accepted: 2018-08-20
Published online: 2018-12-23
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Fig. 1. Open field test results in experimental and control mice with modelled parkinsonism (m ± SEM). * — p < 0.05 compared to the 1st group, ** — p < 0.01 compared to the 1st group, & — p < 0.05 compared to the 2nd group, && — p < 0.01 compared to the 2nd group, # — p < 0.05 compared to the 3rd group, ## — p < 0.01 compared to the 3rd group
Fig. 2. Body length and pace in the experimental and control mice with modelled parkinsonism, mm (m ± SEM). * — p < 0.05 compared to the 1st group, ** — p < 0.01
compared to the 1st group, & — p < 0.05 compared to the 2nd group, && — p < 0.01 compared to the 2nd group, # — p < 0.05 compared to the 3rd group, ## — p < 0.01
compared to the 3rd group
Fig. 3. Tremor and duration of rotation in rota-rod (sec) in experimental and control mice with modelled parkinsonism (m ± SEM). * — p < 0.05 compared to the 1st
group, ** — p < 0.01 compared to the 1st group, & — p < 0.05 compared to the 2nd group, && — p < 0.01 compared to the 2nd group, # — p < 0.05 compared to the 3rd group, ## — p < 0.01 compared to the 3rd group
Table 1. Concentration of BDNF in the brain tissue of mice with modelled parkinsonism after treatment with normal saline and BDNF preparations, pg/mg (m+/–SE)
Note: * — p < 0.05 compared to normal saline; ** — p < 0.01 compared to normal saline; ## — р < 0.01 compared to BDNF; & — p < 0.05 compared to nanoparticulate BDNF.
