2018 / 06

Next Paper
DOI: 10.24075/brsmu.2018.083

OPINION

Poly(3-hydroxyalkanoate)-based drug formulations: the micro- and nanostructure

Bonartsev AP1,2, Bonartseva GA2, Voinova VV1, Kirpichnikov MP1, Shaitan KV1
About authors

1 Faculty of Biology, Lomonosov Moscow State University, Moscow

2 Bakh Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow

Correspondence should be addressed: Anton P. Bonartsev
Leninskie gory, 1 bl. 12, Moscow, 119234; ur.liam@ranob_tna

About paper

Funding: this work was supported by the grant of the Russian Science Foundation (project 17-74-20104, section 1) and the grant of the Russian Foundation for Basic Research (project 15-29-04856, section 2).

Received: 2018-08-26 Accepted: 2018-09-22 Published online: 2018-12-30
|
  1. Bonartsev AP. Poly(3-hydroxybutyrate): applications. In: Mishra M, editor. Encyclopedia of Polymer Applications. Boca Raton: CRC Press, Taylor and Francis Group, 2019; 5250 p. DOI: 10.1201/9781351019422-140000085.
  2. Bonartsev AP, Voinova VV, Bonartseva GA. Poly(3-hydroxybutyrate) and human microbiota. Applied biochemistry and microbiology. 2018; 54 (6): 547–68. DOI: 10.1134/S0003683818060066.
  3. Lee TH, Wang J, Wang CH. Double-walled microspheres for the sustained release of a highly water soluble drug: characterization and irradiation studies. J Control Release. 2002; (83): 437–52.
  4. Dong Y, Feng SS. Poly(D,L-lactide-co-glycolide)/montmorillonite nanoparticles for oral delivery of anticancer drugs. Biomaterials. 2005; (26): 6068–76.
  5. Gu FX, Karnik R, Wang AZ, Alexis F, Levy-Nissenbaum E, Hong S et al. Targeted nanoparticles for cancer therapy. Nano Today. 2007; (2): 14–21.
  6. Brigger I, Dubernet C, Couvreur P. Nanoparticles in cancer therapy and diagnosis Adv Drug Deliv Rev. 2002; (54): 631–51.
  7. Blanco E, Bey EA, Dong Y, Weinberg BD, Sutton DM, Boothman DA, Gao J. β-Lapachone-containing PEG–PLA polymer micelles as novel nanotherapeutics against NQO1-overexpressing tumor cells. J Control Release. 2007; (122): 365–74.
  8. Nguyen A, Marsaud V, Bouclier C, Top S, Vessieres A, Pigeon P, Gref R, Legrand P, Jaouen G, Renoir JM. Nanoparticles loaded with ferrocenyl tamoxifen derivatives for breast cancer treatment. Int J Pharm. 2008; (347): 128–35.
  9. Iwata T et al. Enzymatic Degradation and Adsorption on Poly[(R)- 3-hydroxybutyrate] Single Crystals with Two Types of Extracellular PHB Depolymerases from Comamonas acidovorans YM1609 and Alcaligenes faecalis T1. Macromolecules. 1997; 97 (30): 5290–6.
  10. Capitán MJ, Rueda DR, Ezquerra TA. Inhibition of the crystallization in nanofilms of poly(3-hydroxybutyrate). Macromolecules. 2004; 15 (37): 5653–9.
  11. Liu YX, Chen EQ. Polymer crystallization of ultrathin films on solid substrates. Coordination Chemistry Reviews. 2010; 254 (9–10): 1011–37.
  12. Barnard GN, Sanders JK. J Biol Chem. 1989; 264 (6): 3286–91.
  13. Harrison ST, Chase HA, Amor SR, Bonthrone KM, Sanders JK. Plasticization of poly(hydroxybutyrate) in vivo. Int J Biol Macromol. 1992; 14 (1): 50–6.
  14. Lauzier C, Revol JF, Marchessault RH. FEMS Microbiol Rev. 1992; (103): 299–310.
  15. Sudesh K, Abe H, Doi Y. Synthesis, structure and properties of polyhydroxyalkanoates: biological polyesters. Prog Polym Sci. 2000; (25): 1503–55.
  16. Abe H, Doi Y. Structural effects on enzymatic degradability for poly[(R )-3-hydroxybutyric acid] and its copolymers: mini-review. Int J Biol Macromol. 1999; (25): 185–92.
  17. Schliecker G, Schmidt C, Fuchs S, Wombacher R, Kissel T. Hydrolytic degradation of poly(lactide-co-glycolide) films: effect of oligomers on degradation rate and crystallinity. Int J Pharm. 2003; 266 (1–2): 39-49.
  18. Kunze C, Edgar Bernd H, Androsch R, Nischan C, Freier T, Kramer S, Kramp B, Schmitz KP. In vitro and in vivo studies on blends of isotactic and atactic poly (3-hydroxybutyrate) for development of a dura substitute material. Biomaterials. 2006; 27 (2): 192–201.
  19. Zhujkov VA. Issledovanie izmenenij fiziko-himicheskih svojstv poli-3-oksibutirata i ego sopolimerov v processe biodegradacii in vitro [dissertacija]. M.: 2018.