ISSN Print 2500–1094
ISSN Online 2542–1204
Bulletin of RSMU
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Friedreich ataxia: FXN gene expression and its relationship with DNA methylation pattern
About authors
Research Center of Neurology, Moscow, Russia
Correspondence should be addressed: Ekaterina Yu. Fedotova
Volokolamskoe shosse, 80, Moscow, 125367; moc.liamg@avotodefke
About paper
Funding: the study is supported by grant of the Russian Science Foundation (project № 17-75-20211).
Author contribution: all authors contributed to the study and preparation of the article equally, read and approved the final version before publishing.
Received: 2019-08-22
Accepted: 2019-09-13
Published online: 2019-09-26
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Table 1. Correlation of the FXN gene expression level and the shorter allele repeat expansion length with the methylation level of DOWN-GAA region non-CpG sites
and adjacent CpG sites in patients with FRDA
Note: # — Spearman's rank correlation coefficient (r); * — р < 0.05; «–» — no correlation; mC — methylated cytosine.
Table 2. Correlation of the FXN gene level expression and the methylation level of sites in all studied regions in a combined cohort adjusted for the group
Note: * — р < 0.05.
