ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
Copyright: © 2019 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
ORIGINAL RESEARCH
Friedreich ataxia: FXN gene expression and its relationship with DNA methylation pattern
About authors
Research Center of Neurology, Moscow, Russia
Correspondence should be addressed: Ekaterina Yu. Fedotova
Volokolamskoe shosse, 80, Moscow, 125367; moc.liamg@avotodefke
About paper
Funding: the study is supported by grant of the Russian Science Foundation (project № 17-75-20211).
Author contribution: all authors contributed to the study and preparation of the article equally, read and approved the final version before publishing.
Received: 2019-08-22
Accepted: 2019-09-13
Published online: 2019-09-26
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Table 1. Correlation of the FXN gene expression level and the shorter allele repeat expansion length with the methylation level of DOWN-GAA region non-CpG sites
and adjacent CpG sites in patients with FRDA
Note: # — Spearman's rank correlation coefficient (r); * — р < 0.05; «–» — no correlation; mC — methylated cytosine.
Table 2. Correlation of the FXN gene level expression and the methylation level of sites in all studied regions in a combined cohort adjusted for the group
Note: * — р < 0.05.
