2019 / 05

Next Paper
DOI: 10.24075/brsmu.2019.060

ORIGINAL RESEARCH

Effects of carnosine and lipoic acid in the late stage of Parkinson’s disease in rats

Berezhnoy DS, Fedorova TN, Kulikova OI, Stavrovskaya AV, Abaimov DA, Gushchina AS, Olshansky AS, Voronkov DN, Stvolinsky SL
About authors

Research Center of Neurology, Moscow, Russia

Correspondence should be addressed: Olga I. Kulikova
Volokolamskoe shosse, 80, Moscow, 125367; ur.ygoloruen@avokiluk

About paper

Author contribution: Berezhnoy DS analyzed the literature; planned the study; acquired, analyzed and interpreted the obtained data; prepared the draft of the manuscript and revised its final version. Fedorova TN analyzed the literature; planned the study; analyzed and interpreted the obtained data; revised the manuscript. Kulikova OI analyzed the literature; planned the study; acquired, analyzed and interpreted the obtained data; revised the manuscript. Stavrovskaya AV analyzed the literature; planned the study; acquired, analyzed and interpreted the obtained data; prepared the draft of the manuscript. Abaimov DA acquired, analyzed and interpreted the obtained data; prepared the draft of the manuscript. Gushchina AS planned the study; acquired, analyzed and interpreted the obtained data; prepared the draft of the manuscript. Olshansky AS acquired and analyzed the data; prepared the draft of the manuscript. Voronkov DN acquired analyzed and interpreted the obtained data; prepared the draft of the manuscript. Stvolinsky SL planned the study; acquired, analyzed and interpreted the obtained data; prepared the draft of the manuscript.

Received: 2019-08-12 Accepted: 2019-08-30 Published online: 2019-09-18
|
Fig. 1. Immunostaining for tyrosine hydroxylase in the SN of rats following the intranigral injection of 6-hydroxydopamine. A. Left brain hemisphere of an animal injected with saline. B. Right brain hemisphere of an animal injected with 6-OHDA. Arrows point to the region of neuronal loss in the SN at x10 magnification
Fig. 2. Effects of carnosine and lipoic acid (LA) on the levels of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the left striatum. # — difference from the control group is significant, p < 0.05; * — difference from the 6-OHDA+NaCl group is significant, p < 0.05
Fig. 3. Effects of carnosine and lipoic acid (LA) on the levels of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and 3-methoxytyramine (3-MT) in the right striatum. # — difference from the control group is significant, p < 0.05; * — difference from the 6-OHDA+NaCl group is significant, p < 0.05; * * — p < 0.01
Fig. 4. Effects of carnosine and lipoic acid (LA) on the levels of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in the right striatum. # — difference from the control group is significant, p < 0.05; * — difference from the 6-OHDA+NaCl group is significant, p < 0.05; * * — p < 0.01
Table 1. Points scored on the scale for assessing the neurotic-like behavior demonstrated in the beam walking test. The table describes the types and variations of different behaviors and the score for each type
Table 2. The effects of carnosine and lipoic acid (LA) on rat performance in the tapered beam walking (BW) test and the open field (OF) test. The table shows the results of the post hoc Tukey’s HSD test
Note: * — difference from the 6-OHDA + NaCl group is significant, p < 0.05; # — difference from the control group is significant, p < 0.05.