ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Internal carotid and vertebral artery dissection: morphology, pathophysiology and provoking factors
About authors
Research Center of Neurology, Moscow, Russia
Correspondence should be addressed: Ludmila A. Kalashnikova
Volokolamskoe shosse, 80, Moscow, 125367; ur.xednay@ncnavokinhsalak
About paper
Funding: this study was part of the state assignment for Research Center of Neurology.
Author contribution: Kalashnikova LA, Gubanova MV — literature analysis, data acquisition, processing of the obtained data, manuscript preparation; Gulveskaya TS, Sakharova AV, Chaykovskaya RP, Shabalina AA — data acquisition, analysis and interpretation; Danilova MS — recruitment of participants; Dobrynina LA — processing of the obtained data, manuscript preparation.
Received: 2019-09-03
Accepted: 2019-10-19
Published online: 2019-10-04
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Figure. Arterial wall dysplasia in the internal carotid and vertebral arteries. A. Thinning and splitting of the internal elastic membrane in the dissected ICA siphon (shown by arrows). Staining: Weigert’s elastic stain (fuchselin); x100 magnification. B. Calcium deposits on the internal elastic membrane in the dissected ICA siphon (shown by an arrow). Staining: von Kossa method; x200 magnification. C. Areas of fibrosis (marked by an asterisk) in the tunica media of the extracranial segment of the dissected ICA. Staining: van Gieson’s stain; x200 magnification. D. An area of the tunica media in the dissected ICA siphon containing irregularly oriented myocyts (marked by an arrow). Staining: van Gieson’s stain; x200 magnification. E. Areas of fibrosis and the decreased number of elastic fibers in the tunica media of the intact internal carotid artery (shown by an arrow). Staining: van Gieson’s stain; x200 magnification. F. A fragment of the internal elastic membrane is missing (shown by an arrow) in the intact vertebral artery. Staining: Weigert’s elastic stain (fuchselin); x200 magnification
Table 1. CTD biomarkers in the patients with ICA/VA dissections in the controls (one-way ANOVA)
Note: p — statistical significance; SD — standard deviation.
Table 2. CTD biomarkers in patients with different localization of arterial dissection (one-way ANOVA and post-hoc tests + Scheffe's procedure)
Note: p — statistical significance; ICA — internal carotid artery; VA — vertebral artery; SD — standard deviation.
