Funding: the study was carried out under state order for Karelian Research Centre (ID 0218-2019-0083; Modification of transcription programs of regulatory T cell differentiation in immunoinflammatory diseases and cancer). Its publication was sponsored by Prime Papers LLC.

Acknowledgements: the authors thank the Center for Precision Genome Editing and Genetic Technologies for Biomedicine (Moscow) for consultations.

Author contribution: Churov AV — article design, literature analysis, preparation of the manuscript draft and its final version; Syutkina AI — article design, the major contribution to literature analysis, preparation of the manuscript draft and its final version; Mamashov KY — article design, literature analysis, preparation of the manuscript draft and its final version; Oleinik EK — literature analysis, preparation of the manuscript draft and its final version.