ORIGINAL RESEARCH

Lipidome features in patients with different probability of family hypercholesterolemia

About authors

1 Central State Medical Academy of the Department of Presidential Affairs of the Russian Federation, Moscow, Russia

2 City Clinical Hospital № 51, Moscow, Russia

3 Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences, Moscow, Russia

4 Lomonosov Moscow State University, Moscow, Russia

Correspondence should be addressed: Larisa O. Minushkina
Filevsky Boulevard, 36–19, Moscow, 121601; ur.liam@anikhsunim

About paper

Funding: RFBR grant 19-04-00870А Sphingolipidome Analysis of Cardiovascular Diseases’ Markers.

Author contribution: Rogozhina AA — sampling, data acquisition; Minushkina LO — data analysis, text writing; Zateyshchikov DA — planning, data analysis, manuscript writing; Alessenko AV — project manager; Gutner UA, Shupik MA, Maloshitskaya OA and Sokolov SA — sample preparation, laboratory analysis, data analysis; Kurochkin IN — data analysis.

Received: 2019-11-30 Accepted: 2019-12-18 Published online: 2019-12-27
|
  1. Matanes F, Twal WO, Hammad SM. Sphingolipids as biomarkers of disease. Adv Exp Med Biol. 2019; (1159): 109–38. DOI: 10.1007/978-3-030-21162-2_7.
  2. Anroedh S, Hilvo M, Akkerhuis KM, Kauhanen D, Koistinen K, Oemrawsingh R, et al. Plasma concentrations of molecular lipid species predict long-term clinical outcome in coronary artery disease patients. J Lipid Res. 2018; 59 (9): 1729–37. DOI: 10.1194/jlr.P081281.
  3. Sutter I, Klingenberg R, Othman A, Rohrer L, Landmesser U, Heg D, et al. Decreased phosphatidylcholine plasmalogens — a putative novel lipid signature in patients with stable coronary artery disease and acute myocardial infarction. Atherosclerosis. 2016; (246): 130–40. DOI: 10.1016/j.atherosclerosis.2016.01.003.
  4. Ng TW, Ooi EM, Watts GF, Chan DC, Meikle PJ, Barrett PH. Association of plasma ceramides and sphingomyelin with VLDL apoB-100 fractional catabolic rate before and after rosuvastatin treatment. J Clin Endocrinol Metab. 2015; 100 (6): 2497–501. DOI: 10.1210/jc.2014-4348. PubMed PMID: 25816050.
  5. Tarasov K, Ekroos K, Suoniemi M, Kauhanen D, Sylvänne T, Hurme R, et al. Molecular lipids identify cardiovascular risk and are efficiently lowered by simvastatin and PCSK9 deficiency. J Clin Endocrinol Metab. 2014; 99 (1): E45–52. DOI:10.1210/jc.2013- 2559. PubMed PMID: 24243630; PubMed Central PMCID: PMC3928964.
  6. Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol. 1959; 37 (8): 911–7.
  7. Hoogendoorn A, den Hoedt S, Hartman EMJ, Krabbendam-Peters I, Te Lintel Hekkert M, van der Zee L, et al. Variation in coronary atherosclerosis severity related to a distinct LDL (Low-Density Lipoprotein) profile: findings from a familial hypercholesterolemia pig model. Arterioscler Thromb Vasc Biol. 2019; 39 (11): 2338–52. DOI:10.1161/ATVBAHA.119.313246.
  8. Sokolowska E, Blachnio-Zabielska A. The role of ceramides in insulin resistance. Front Endocrinol (Lausanne). 2019; (10): 577. DOI: 10.3389/fendo.2019.00577.
  9. Kayser BD, Lhomme M, Dao MC, Ichou F, Bouillot JL, Prifti E, et al. Serum lipidomics reveals early differential effects of gastric bypass compared with banding on phospholipids and sphingolipids independent of differences in weight loss. Int J Obes (Lond). 2017; 41 (6): 917–25. DOI: 10.1038/ijo.2017.63.
  10. Paul A, Lydic TA, Hogan R, Goo YH. Cholesterol acceptors regulate the lipidome of macrophage foam cells. Int J Mol Sci. 2019; 20 (15): E3784–801. DOI: 10.3390/ijms20153784.
  11. Jiménez-Rojo N, Viguera AR, Collado MI, Sims KH, Constance C, Hill KS et al. Sphingosine induces the aggregation of imine-containing peroxidized vesicles. Biochim Biophys Acta. 2014; 1838 (8): 2071–7. DOI: 10.1016/j.bbamem.2014.04.028.
  12. Karjalainen JP, Mononen N, Hutri-Kähönen N, Lehtimäki M, Hilvo M(4), Kauhanen D, et al. New evidence from plasma ceramides links apoE polymorphism to greater risk of coronary artery disease in Finnish adults. J Lipid Res. 2019; 60 (9): 1622–9. DOI: 10.1194/ jlr.M092809.
  13. Zhao W, Wang X, Deik AA, Hanna DB, Wang T, Haberlen SA et al. Elevated plasma ceramides are associated with antiretroviral therapy use and progression of carotid artery atherosclerosis in HIV infection. Circulation. 2019; 139 (17): 2003–11. DOI: 0.1161/ CIRCULATIONAHA.118.037487.
  14. Chen Y, Wen S, Jiang M, Zhu Y, Ding L, Shi H, et al. Atherosclerotic dyslipidemia revealed by plasma lipidomics on ApoE-/- mice fed a high-fat diet. Atherosclerosis. 2017; (262): 78–86. DOI: 10.1016/j. atherosclerosis.2017.05.010.
  15. Law BA, Liao X, Moore KS, Southard A, Roddy P, Ji R, et al. Lipotoxic very-long-chain ceramides cause mitochondrial dysfunction, oxidative stress, and cell death in cardiomyocytes. FASEB J. 2018; 32 (3): 1403–16. DOI: 10.1096/fj.201700300R. PubMed PMID: 29127192; PubMed Central PMCID: PMC5892719.