2020 / 03

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DOI: 10.24075/brsmu.2020.027

ORIGINAL RESEARCH

Aspects of free radical oxidation in the large bowel in ulcerative colitis and Crohn’s disease

Osikov MV1, Davydova EV1, Boyko MS1, Bakeeva AE1, Kaygorodtseva NV1, Galeeva IR1, Fedosov AA2, Ilyinyh MA1, Vorgova LV1
About authors

1 South Ural State Medical University, Chelyabinsk

2 Pirogov Russian National Research Medical University, Moscow, Russia

Correspondence should be addressed: Mikhail V. Osikov
Vorovskogo, 64, Chelyabinsk, 454092; ur.xednay@vokiso.forp

About paper

Compliance with ethical standards: the study was approved by the Ethics Committee of South Ural State Medical University, Chelyabinsk (Protocol No. 11 dated December 27, 2017; Protocol № 1 dated January 22, 2020). The experiment was carried out under standard vivarium conditions in strict compliance with the guidelines on the care and use of animals for scientific purposes provided in the European Convention (ETS № 123 dated March 18, 1986, Strasbourg), European Commission Recommendation 2007/526/EC dated June 18, 2007, and Directive 2010/63/EU of the European Parliament and European Council dated September 22, 2010.

Author contribution: Osikov MV conceived and designed the study, analyzed the experimental data and contributed to writing the manuscript; Davydova EV conceived and designed the study, analyzed the experimental data and contributed to writing the manuscript; Boyko MS, Bakeeva AE, Kaygorodtseva NV, Galeeva IR collected the samples, performed statistical analysis and data interpretation; Fedosov AA analyzed the experimental data and contributed to writing the manuscript; Ilyinyh MA, Vorgova LV analyzed the experimental data and contributed to writing the manuscript. All authors read and approved the final version of the manuscript for publication.

Received: 2020-04-18 Accepted: 2020-05-04 Published online: 2020-05-08
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Table 1. Parameters assessed by DAI
Table 2. Disease activity index in rats with UC and CD (Me (Q25–Q75))
Table 3. Markers of free radical oxidation in the homogenate of large intestinal mucosa of rats with CD and UC (Me (Q25–Q75))
Note: * — difference is significant (р < 0.01) relative to group 1, # — relative to group 2. The listed parameters reflect the content of LPO products in the heptane (g) and isopropanol (i) phases of the lipid extract from the mucosal homogenate of the large intestine
Table 4. Correlations between DAI scores (c.u.) and FRO in rats with experimentally induced UC and CD
Note: significant correlations (р < 0.05) are shown in bold.