Compliance with ethical standards: the study was approved by the Ethics Committee of South Ural State Medical University, Chelyabinsk (Protocol No. 11 dated December 27, 2017; Protocol № 1 dated January 22, 2020). The experiment was carried out under standard vivarium conditions in strict compliance with the guidelines on the care and use of animals for scientific purposes provided in the European Convention (ETS № 123 dated March 18, 1986, Strasbourg), European Commission Recommendation 2007/526/EC dated June 18, 2007, and Directive 2010/63/EU of the European Parliament and European Council dated September 22, 2010.

Author contribution: Osikov MV conceived and designed the study, analyzed the experimental data and contributed to writing the manuscript; Davydova EV conceived and designed the study, analyzed the experimental data and contributed to writing the manuscript; Boyko MS, Bakeeva AE, Kaygorodtseva NV, Galeeva IR collected the samples, performed statistical analysis and data interpretation; Fedosov AA analyzed the experimental data and contributed to writing the manuscript; Ilyinyh MA, Vorgova LV analyzed the experimental data and contributed to writing the manuscript. All authors read and approved the final version of the manuscript for publication.