ISSN Print 2500–1094
ISSN Online 2542–1204
Bulletin of RSMU
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Effect of neuromodulation on neurotrophic factors in patients with chronic disorders of consciousness
About authors
Research Center of Neurology, Moscow, Russia
Correspondence should be addressed: Elizaveta G. Iazeva
Volokolamskoye shosse, 80, Moscow, 125367; ur.ygoloruen@avezay
About paper
Funding: the study was supported by Russian Science Foundation (RSF) grant 16-15-00274.
Compliance with ethical standards: the study was approved by the Ethics Committee of the Research Center of Neurology (protocol No. 9-5.16 dated October 26, 2016). Patients were included in the study after obtaining the informed consent from their legal representatives.
Author contribution: Iazeva EG — clinical practice, clinical assessment, collecting biomaterials, manuscript writing; Legostaeva LA — clinical practice, clinical assessment, collecting biomaterials; Bakulin IS, Poydasheva AG — рТМС, manuscript writing; Abaimov DA, Shabalina AA — laboratory tests; Suponeva NA, Ryabinkina YV, Piradov MA — study planning and management.
Received: 2020-08-19
Accepted: 2020-09-05
Published online: 2020-09-24
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Figure. Change of BDNF levels in the cerebrospinal fluid of patients with chronic DOC after the course of rTMS by groups according to DOC type and etiology. VS — vegetative state; MCS — minimally conscious state; DOC — disorder of consciousness; TBI — traumatic brain injury
Table 1. Baseline characteristics of patients included in the study of biochemical markers in chronic DOC
Note: VS — vegetative state; non-traum. — non-traumatic; MCS — minimally conscious state; DOC — chronic disorder of consciousness; TBI — traumatic brain injury.
Table 2. Serum biomarkers levels in patients with chronic DOC and healthy volunteers
Note: VS — vegetative state; non-traum. — non-traumatic; MCS — minimally conscious state; DOC — chronic disorder of consciousness; TBI — traumatic brain injury.
Table 3. Cerebrospinal fluid biomarkers levels in patients with chronic DOC
Note: VS — vegetative state; non-traum. — non-traumatic; MCS — minimally conscious state; DOC — chronic disorder of consciousness; TBI — traumatic brain injury.
