2020 / 06

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DOI: 10.24075/brsmu.2020.085

ORIGINAL RESEARCH

Interleukin dynamics during cognitive stress in patients with chronic cerebral ischemia

Fokin VF, Shabalina AA, Ponomareva NV, Medvedev RB, Lagoda OV, Tanashyan MM
About authors

Research Center of Neurology, Moscow, Russia

Correspondence should be addressed: Vitaly Fedorovich Fokin
Volokolamskoe shosse, 80, Moscow, 125367; ur.liam@fvf

About paper

Author contribution: Fokin VF performed data analysis and wrote the manuscript; Shabalina AA performed biochemical analysis of cytokines and participated in writing the manuscript; Ponomareva NV collected and analyzed psychometric data, participated in writing the manuscript; Medvedev RB performed clinical examinations, analyzed the literature and proposed the study design; Lagoda OV analyzed clinical data and proposed the study design; Tanashyan MM proposed the study design, summarized clinical data in the context of the obtained results.

Compliance with ethical standards: the study was approved by the Ethics Committee of the Research Center of Neurology (Protocol No. 11/14 dated November 19, 2014); all study participants signed informed consent to participate.

Received: 2020-11-06 Accepted: 2020-12-17 Published online: 2020-12-28
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Fig. 1. Performance during cognitive tests in groups 1 and 2 of IL1β shifts. ‒1 — group 1, 1 — group 2. A. Number of subtraction mistakes (100–7). B. Delayed words recall in the Luria test
Fig. 2. Cognitive test performance in patients with negative or positive IL10 response. The legend is the same as in Fig. 1
Table 1. Statistical characteristics of interleukin levels before and after cognitive tests
Note: р — level of statistical significance.
Table 2. Shifts in IL1β and IL10 salivary concentrations following cognitive stress in 2 groups of patients
Note: р — level of statistical significance.
Table 3. Associations between shifts in IL1β concentrations and cognitive function
Note: F — Fisher’s coefficient; р — level of significance.
Table 4. Associations between IL10 response and cognitive function
Note: F — Fisher’s coefficient; р — level of significance.