![](/i/rsmu-medium-clean.png)
ORIGINAL RESEARCH
Brain atrophy patterns in patients with frontotemporal dementia: voxel-based morphometry
1 Research Center of Neurology, Moscow, Russia
2 Sechenov First Moscow State Medical University, Moscow, Russia
3 Pirogov Russian National Research Medical University, Moscow, Russia
Correspondence should be addressed: Dilyara R. Akhmadullina
Volokolamskoye shosse, 80, Moscow, 125367; moc.liamg@1rdanilludamhka
Funding: the study was supported by the Russian Foundation for Basic Research (grant № 19-015-00533).
Author contribution: Akhmadullina DR — clinical assessment, data analysis and interpretation, literature analysis, manuscript writing; Konovalov RN — data analysis and interpretation, study planning and management; Shpilyukova YuA, Grishina DA — clinical assessment, manuscript draft preparation; Berdnikovich ES — clinical assessment; Fomenko SS — data analysis and interpretation, literature analysis, manuscript writing; Fedotova EYu — study planning and management; Illarioshkin SN — study planning and management.
- Finger EC. Frontotemporal Dementias. Continuum. 2016; 22: 464–89.
- Bergeron D, Gorno-Tempini ML, Rabinovici GD, Santos-Santos MA, Seeley W, Miller BL, et al. Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia. Ann Neurol. 2018; 84 (5): 729–40.
- Grishina DA, Yakhno NN, Zakharov VV. Emotional, affective and behavioral disorders in a behavioral variant of frontotemporal dementia. S.S. Korsakov Journal of Neurology and Psychiatry. 2017; 117 (11): 13.
- Olney NT, Spina S, Miller BL. Frontotemporal Dementia. Neurol Clin. 2017; 35 (2): 339–74.
- Shpilyukova YuA, Fedotova EYu, Illarioshkin SN. Genetic diversity of frontotemporal dementia. Molecular Biology. 2020; 54 (1): 17–28.
- Mackenzie IRA, Neumann M. Molecular neuropathology of frontotemporal dementia: insights into disease mechanisms from postmortem studies. J Neurochem. 2016; 54–70.
- Gorno-Tempini ML, Hillis AE, Weintraub S, Kertesz A, Mendez M, Cappa SF, et al. Classification of primary progressive aphasia and its variants. Neurology. 2011; 76 (11): 1006–14.
- Rascovsky K, Hodges JR, Knopman D, Mendez MF, Kramer JH, Neuhaus J, et al. Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain. 2011 Sep; 134 (9): 2456–77.
- Vijverberg EGB, Wattjes MP, Dols A, Krudop WA, Möller C, Peters A, et al. Diagnostic Accuracy of MRI and Additional [18F]FDG-PET for Behavioral Variant Frontotemporal Dementia in Patients with Late Onset Behavioral Changes. J Alzheimer’s Dis. 2016; 53 (4): 1287–97.
- Harper L, Fumagalli GG, Barkhof F, Scheltens P, O’Brien JT, Bouwman F, et al. MRI visual rating scales in the diagnosis of dementia: Evaluation in 184 post-mortem confirmed cases. Brain. 2016; 139 (4): 1211–25.
- Pan PL, Song W, Yang J, Huang R, Chen K, Gong QY, et al. Gray Matter Atrophy in Behavioral Variant Frontotemporal Dementia: A Meta-Analysis of Voxel-Based Morphometry Studies. Dement Geriatr Cogn Disord. 2012; 33 (2–3): 141–8.
- Rohrer JD, Ridgway GR, Modat M, Ourselin S, Mead S, Fox NC, et al. Distinct profiles of brain atrophy in frontotemporal lobar degeneration caused by progranulin and tau mutations. Neuroimage. 2010; 53 (3): 1070–6.
- Mahoney CJ, Beck J, Rohrer JD, Lashley T, Mok K, Shakespeare T, et al. Frontotemporal dementia with the C9ORF72 hexanucleotide repeat expansion: clinical, neuroanatomical and neuropathological features. Brain. 2012; 135 (3): 736–50.
- Josephs KA, Whitwell JL, Parisi JE, Petersen RC, Boeve BF, Jack CR, et al. Caudate atrophy on MRI is a characteristic feature of FTLD-FUS. Eur J Neurol. 2010; 17 (7): 969–75.
- Schroeter ML, Raczka K, Neumann J, Yves von Cramon D. Towards a nosology for frontotemporal lobar degenerations — A meta-analysis involving 267 subjects. Neuroimage. 2007 Jul; 36 (3): 497–510.
- Seeley WW. Behavioral Variant Frontotemporal Dementia. Contin Lifelong Learn Neurol. 2019 Feb; 25 (1): 76–100.
- Folegatti A, Pia L, Berti A, Cubelli R. Stress assignment errors in surface dyslexia: Evidence from two Italian patients with a selective deficit of the orthographic input lexicon. Behav Neurol. 2015; 2015: 1–8.
- Canu E, Agosta F, Battistella G, Spinelli EG, DeLeon J, Welch AE, et al. Speech production differences in English and Italian speakers with nonfluent variant PPA. Neurology. 2020; 94 (10): e1062–72.
- Shpilyukova YuA, Yusupova DG, Akhmadullina DR, Polekhina NV, Naminov AV, Sinelnikov ME, et al. Frontotemporal dementia rating scale (FTD-FRS): linguistic and cultural adaptation in Russia. Annals of Clinical and Experimental Neurology. 2020; 14 (2): 82–7.
- xjView. Version 9.6 [software]. Available from: http://www. alivelearn.net/xjview.
- Tetzloff KA, Utianski RL, Duffy JR, Clark HM, Strand EA, Josephs KA, et al. Quantitative analysis of agrammatism in agrammatic primary progressive aphasia and dominant apraxia of speech. J Speech, Lang Hear Res. 2018; 61 (9): 2337–46.
- Whitwell JL, Duffy JR, Strand EA, Xia R, Mandrekar J, Machulda MM, et al. Distinct regional anatomic and functional correlates of neurodegenerative apraxia of speech and aphasia: An MRI and FDG-PET study. Brain Lang. 2013; 125 (3): 245–52.
- Brambati SM, Amici S, Racine CA, Neuhaus J, Miller Z, Ogar J, et al. Longitudinal gray matter contraction in three variants of primary progressive aphasia: A tenser-based morphometry study. NeuroImage Clin. 2015; 8: 345–55.
- Bickart KC, Brickhouse M, Negreira A, Sapolsky D, Barrett LF, Dickerson BC. Atrophy in distinct corticolimbic networks in frontotemporal dementia relates to social impairments measured using the social impairment rating scale. J Neurol Neurosurg Psychiatry. 2014; 85 (4): 438–48.
- Sheelakumari R, Bineesh C, Varghese T, Kesavadas C, Verghese J, Mathuranath PS. Neuroanatomical correlates of apathy and disinhibition in behavioural variant frontotemporal dementia. Brain Imaging Behav. 2020 Oct; 14 (5): 2004–11.
- Oberhuber M, Hope TMH, Seghier ML, Parker Jones O, Prejawa S, Green DW, et al. Four Functionally Distinct Regions in the Left Supramarginal Gyrus Support Word Processing. Cereb Cortex. 2016; 26 (11): 4212–26.
- Preiß D, Billette OV, Schneider A, Spotorno N, Nestor PJ. The atrophy pattern in Alzheimer-related PPA is more widespread than that of the frontotemporal lobar degeneration associated variants. NeuroImage Clin. 2019; 24: 101994.
- Bisenius S, Neumann J, Schroeter ML. Validating new diagnostic imaging criteria for primary progressive aphasia via anatomical likelihood estimation meta-analyses. Eur J Neurol. 2016; 23 (4): 704–12.
- Ballard KJ, Savage S, Leyton CE, Vogel AP, Hornberger M, Hodges JR. Logopenic and Nonfluent Variants of Primary Progressive Aphasia Are Differentiated by Acoustic Measures of Speech Production. PLoS One. 2014; 9 (2): e89864.