2021 / 01

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DOI: 10.24075/brsmu.2021.003

ORIGINAL RESEARCH

Bone turnover markers in patients with isolated femoral shaft fracture undergoing systemic ozone therapy

Osikov MV, Davydova EV, Abramov KS
About authors

South-Ural State Medical University, Chelyabinsk, Russia

Correspondence should be addressed: Mikhail V. Osikov
Vorovskogo, 64, Chelyabinsk, 454092; ur.xednay@vokiso.forp

About paper

Author contribution: Osikov MV conceived the study, proposed its design, analyzed the obtained data, wrote and edited the manuscript; Davidova EV conceived the study, proposed its design, analyzed the obtained data, participated in writing the manuscript; Abramov KS collected clinical data, analyzed the results of the study, wrote and edited the manuscript. The authors equally contributed to the study and preparation of the manuscript, read and approved the final version of this article before publication.

Compliance with ethical standards: the study was approved by the Ethics Committee of the South Ural State Medical University, Chelyabinsk (Protocol № 4 dated May 22, 2020). Informed consent was obtained from all study participants.

Received: 2020-12-29 Accepted: 2021-01-17 Published online: 2021-02-02
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Table 1. Bone mineral density and RUST scores for the periosteal callus in patients with a closed isolated femoral shaft fracture, (Me [Q25; Q75])
Note: * — differences are significant (р < 0.05; the Mann–Whitney, Kruskal–Wallis, Wilcoxon and Wild–Wolfowitz tests) for comparison with the healthy leg.
Table 2. Bone mineral density and RUST scores at the site of the periosteal callus in patients with an isolated closed femoral shaft fracture in the setting of ozone therapy (Me [Q25; Q75])
Note: * — differences are significant (р < 0.05; the Mann–Whitney, Kruskal–Wallis, Wilcoxon and Wild–Wolfowitz tests) for comparison with the healthy leg; # — differences are significant for comparison with subgroup 2a.
Table 3. Levels of C-terminal telopeptides of type I collagen in patients with an isolated femoral fracture undergoing ozone therapy (Me [Q25; Q75])
Note: * — differences are significant (р < 0.05; the Mann–Whitney, Kruskal–Wallis, Wilcoxon and Wild–Wolfowitz tests) for comparison with the control group; # — differences are significant for comparison with subgroup 2a.
Table 4. Levels of procollagen type I carboxy-terminal propeptide (PICP) in patients with an isolated femoral fracture undergoing ozone therapy (Me [Q25; Q75])
Note: * — differences are significant (р < 0.05; the Mann–Whitney, Kruskal–Wallis, Wilcoxon and Wild–Wolfowitz tests) for comparison with the control group; # — differences are significant for comparison with subgroup 2a.