Author contribution: Osikov MV conceived the study, proposed its design, analyzed the obtained data, wrote and edited the manuscript; Davidova EV conceived the study, proposed its design, analyzed the obtained data, participated in writing the manuscript; Abramov KS collected clinical data, analyzed the results of the study, wrote and edited the manuscript. The authors equally contributed to the study and preparation of the manuscript, read and approved the final version of this article before publication.

Compliance with ethical standards: the study was approved by the Ethics Committee of the South Ural State Medical University, Chelyabinsk (Protocol № 4 dated May 22, 2020). Informed consent was obtained from all study participants.