ORIGINAL RESEARCH

Refinement of noninvasive methods for diagnosing precancer and cancer of oral mucosa in general dental practice

Postnikov MA1, Gabrielyan AG1,2, Trunin DA1, Kaganov OI1,2, Kirillova VP1, Khamadeeva AM1, Osokin OV2, Kopetskiy IS3, Eremin DA
About authors

1 Samara State Medical University, Samara, Russia

2 Samara Regional Clinical Cancer Center, Samara, Russia

3 Pirogov Russian National Research Medical University, Moscow, Russia

Correspondence should be addressed: Alexey G. Gabrielyan
Michurina, 138, kv. 85, Samara, 443086; ur.liam@200_leirbag

About paper

Author contribution: Postnikov MA — literature analysis; Gabrielyan AG — study planning; Trunin DA, Kopetskiy IS, Eremin DA — analysis of the obtained data; Kaganov OI — manuscript draft; Kirillova VP — analysis of patients’ records; Khamadeeva AM — interpretation of the obtained results; Osokin OV — data acquisition.

Compliance with ethical standards: the study was approved by the Ethics Committee of Samara State Medial University (Protocol № 27 dated February 12, 2018).

Received: 2020-12-18 Accepted: 2021-01-29 Published online: 2021-02-17
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Fig. 1. An algorithm for assessing indications for biopsy in patients with vermillion lip border and oral mucosa neoplasia presenting to a dentist for a clinical examination
Fig. 2. Biopsy of a buccal mucosa lesion
Fig. 3. Lingual mucosa lesion detected on clinical examination
Fig. 4. Brown autofluorescence of lingual mucosa under AFS400 light
Fig. 5. Distribution of presenting complaints in the main (M1) and control (M2) groups on clinical examination
Fig. 6. Distribution of patients in the groups by histologically verified diagnoses
Fig. 7. Distribution of patients in the groups by cancer stages
Table 1. Lesions sites in the main and control groups
Note: Pearson’s coefficient = 2.7567; р = 0.8386.
Table 2. Presenting complaints in the main (M1) and control (M2) groups
Table 3. Clinical manifestations detected on examination in the main (M1) and control (M2) groups (under natural light)