2021 / 01

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DOI: 10.24075/brsmu.2021.006

ORIGINAL RESEARCH

Characteristics of BRCA-associated breast cancer in the population of the Russian Federation

Novikova EI, Kudinova EA, Bozhenko VK, Solodkiy VA
About authors

Russian Scientific Center for Roentgenoradiology, Moscow, Russia

Correspondence should be addressed: Ekaterina I. Novikova
Profsoyuznaya, 86, Moscow, 117997; ur.liam@rrcnr.avokivon.e

About paper

Author contribution: Novikova EI — collection of clinical material, conducting molecular genetic studies, analysis and statistical processing of the results, preparation and writing of the article; Kudinova EA — analysis of literature, analysis of the research results; Bozhenko VK — analysis of the results, article text editing; Solodkiy VA — planning and analysis of the research results, article test editing.

Compliance with ethical standards: the study was approved by the ethics committee of the RSCR (minutes #3 of March 27, 2020); all patients included in the study signed a voluntary informed consent.

Received: 2021-01-02 Accepted: 2021-02-15 Published online: 2021-02-22
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Table 1. Clinical characteristics of the examined BC patients group
Note: PMMN — primary multiple malignant neoplasms.
Table 2. Frequency of occurrence of BRCA1 and BRCA2 gene mutations most common in the population (BC patients)
Table 3. Characteristics and frequency of rare pathogenic BRCA1 and BRCA2 sequence variants, CSHD BC patients group
Table 4. Comparison of BRCA1- and BRCA2-associated BC, main clinical and morphological characteristics
Note: * — significant differences with the BRCA1-associated BC group (p < 0.05); PMMN — primary multiple malignant neoplasms.