2021 / 01

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DOI: 10.24075/brsmu.2021.007

ORIGINAL RESEARCH

Associations between glutamate cysteine ligase catalytic subunit gene polymorphisms and clinical characteristics of ischemic stroke

Bocharova YuA1,2
About authors

1 Belgorod State National Research University, Belgorod, Russia

2 Kursk Regional Clinical Hospital, Kursk, Russia

Correspondence should be addressed: Yulia A. Bocharova
Sumskaya, 45a, Kursk, 305007; ur.liam@30_a_i_l_u_y

About paper

Acknowledgements: the author thanks Polonikov AV, Azarova YuE, Klyosova EYu, Bykanova MA and Bushueva OYu of the Research Institute of Genetic and Molecular Epidemiology (Kursk State Medical University) for their help in conducting molecular genetic studies.

Compliance with ethical standards: the study was approved by the Ethics Committee of Kursk State Medical University (Protocol № 5 dated June 25, 2012); all study participants gave voluntary informed consent to participate.

Received: 2021-01-21 Accepted: 2021-02-06 Published online: 2021-02-23
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Fig. Associations between the rs17883901 polymorphism of the GCLC gene and age at ischemic stroke onset
Table 1. Summary of the associations between GCLC polymorphisms and the number of past ischemic strokes
Note: 1 — indicates the significance of the association with the risk of 2 or more IS adjusted for age and sex; 2 — OR and 95% CI for the associations between the studied SNPs and the risk of 2 or more IS adjusted for age and sex.
Table 2. Effects of GCLC polymorphisms on its expression in the brain, arteries and blood (https://www.gtexportal.org)
Note: 1 The allele that was analyzed for the possible effect on GCLC expression is shown in bold. Significant effects of SNPs on GCLC expression (p ≤ 0.05) are shown in bold. * — p — the level of statistical significance and the Z — score describing the effects of a given SNP on GCLC expression in the blood (eQTLGen, www.eqtlgen.org).