ORIGINAL RESEARCH

The impact of the novel coronavirus infection COVID-19 on the mother-placenta-fetus system

About authors

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia

Correspondence should be addressed: Natalia A. Lomova
Oparina, 4, Moscow, 117997; ur.xednay@avomol-ahsatan

About paper

Funding: the study was supported by RFBR grant № 20-04-60093.

Acknowlegements: here we would like to thank Sinitsina VA, medical laboratory assistant of the 2nd Anatomical Pathology Department of the Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, and Bugrova AV, senior research scientist of the Laboratory for Proteomics and Metabolomics of Human Reproduction of the Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology.

Author contribution: Nizyaeva NV — pathomorphological study and IHC analysis, systematic analysis, manuscript writing; Lomova NA — analysis of clinical data, systematic analysis, manuscript writing; Dolgopolova EL — collection and preparation of biological matrix samples in the red zone, statistical analysis of the results; Petrova UL — collection and preparation of biological matrix samples in the red zone; Karapetyan ТE — analysis of clinical data; Shmakov RG — analysis of clinical data in the red zone, systematic analysis, manuscript editing; Frankevich VE — preparation of the study, systematic analysis.

Compliance with ethical standards: all patients submitted the informed consent to participate in the study; the study met the requirements of the Declaration of Helsinki, International Conference on Harmonization (ICF), Good Clinical Practice (GCP), and Federal Law No. 323-FZ “On the Basics of Protecting Citizens' Health in the Russian Federation” of November 21, 2011.

Received: 2021-04-14 Accepted: 2021-04-25 Published online: 2021-04-30
|
  1. Zhu H, Wang L, Fang C, Peng S, Zhang L, Chang G, et al. Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. Transl Pediatr. 2020; 9 (1): 51–60. DOI: 10.21037/ tp.2020.02.06.
  2. Liu Y, Chen H, Tang K, Guo Y. Clinical manifestations and outcome of SARS-CoV-2 infection during pregnancy. J Infect. 2020; DOI: 10.1016/j.jinf.2020.02.028.
  3. Varga Z, Flammer AJ, Steiger P, Haberecker M, Andermatt R, Zinkernagel AS, et al. Endothelial cell infection and endotheliitis in COVID-19. Lancet. 2020; 395 (10234): 1417–8. DOI: 10.1016/ S0140-6736(20)30937-5.
  4. Dashraath P, Wong JLJ, Lim MXK, Lim LM, Li S, Biswas A, et al. Coronavirus disease 2019 (COVID-19) pandemic and pregnancy. Am J Obstet Gynecol. 2020; 222 (6): 521–31. DOI: 10.1016/j. ajog.2020.03.021.
  5. Schwartz DA, Graham AL. Potential maternal and infant outcomes from coronavirus 2019-NCOV (SARS-CoV-2) infecting pregnant women: Lessons from SARS, MERS, and other human coronavirus infections. Viruses. 2020; 12 (2): 194. DOI: 10.3390/ v12020194.
  6. Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020; 395 (10226): 809–15. DOI: 10.1016/S0140-6736(20)30360-3.
  7. Baev OR, Karapetyan AO, Nizyaeva NV, Sadekova AA, Krasny AM. Soderzhanie vnekletochnoj DNK ploda v materinskoj krovi i jekspressija DNK-raspoznajushhih ZBP-1 receptorov v strukturah placenty pri prejeklampsii i prezhdevremennyh rodah. 2019; 3: 179–84. Russian.
  8. Becker RC, et al. COVID-19-associated vasculitis and vasculopathy. Journal of thrombosis and thrombolysis, 2020; 50 (3): 499–511. Аvailable from: https://doi.org/10.1007/s11239-020-02230-4.
  9. Hosier H, Farhadian SF, et al. SARS–CoV-2 infection of the placenta. 2020; J Clin Invest. 2020; 130 (9): 4947–53. Аvailable from: https://doi.org/10.1172/JCI139569.
  10. Issa AH, Jaber BMS. Evaluation of predictive ability for the indicator of natal cord coils of the pregnant women. World J Pharm Res. 2019; 8 (5): 197–208.
  11. Bitsadze VO, Makatsariya AD, Hizroeva DH, Makatsariya NA, Yashenina EV, Kazakova LA. Thrombophilia as the most important link of the pathogenesis of pregnancy complications. Practical medicine. 2012; 9 (65): 24–31. Russian.
  12. Shchyogolev AI, Dubova EA, Pavlov KA, Lyapin VM, Kulikova GV, Shmakov RG. Morphometric characteristics of terminal villi of the placenta in preeclampsia. Bulletin of Experimental Biology and Medicine. 2013; 154 (1): 92–95.
  13. Nizyaeva NV, Prihodko AM, Evgrafova AV, Tysyachny OV, Baev OR. Kliniko-morfologicheskie osobennosti placenty pri ostroj vnutriutrobnoj gipoksii v rodah. Akusherstvo i ginekologija. 2019; 12: 96–104. Dostupno po ssylke: https://dx.doi.org/10.18565/ aig.2019.12.96-104. Russian.
  14. Hcini N, Maamri F, Picone O, Carod JF, Lambert V, Mathieu M, et al. Maternal, fetal and neonatal outcomes of large series of SARSCoV-2 positive pregnancies in peripartum period: A single-center prospective comparative study. European journal of obstetrics, gynecology, and reproductive biology. 2020; 257: 11–18. Аvailable from: https://doi.org/10.1016/j.ejogrb.2020.11.068.