ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Changes in gut microbiota composition and their associations with cortisol, melatonin and interleukin 6 in patients with chronic insomnia
About authors
V.I. Vernadsky Crimean Federal University, Simferopol, Russia
Correspondence should be addressed: Lesya N. Gumenyuk
Lenin boulevard, 5/7, Simferopol, Republic of Crimea, 295006; ur.liam@kuynemyg_aysel
About paper
Author contribution: Masyutina AA, Fatovenko YuV collected, analyzed and interpreted the obtained data; Gumenyuk LN proposed the concept and design for the study; Sorokina LE, Bayramova SS, Alekseenko AA performed statistical analysis; Shavrov YuV, Romanova AA, Seydametova DI wrote the manuscript.
Compliance with ethical standards: the study was approved by the Ethics Committee of Georgievsky Medical Academy (Protocol № 10 dated November 16, 2020) and complied with the Declaration of Helsinki. Voluntary informed consent was obtained from all study participants.
Received: 2021-03-07
Accepted: 2021-04-14
Published online: 2021-04-27
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Fig. 1. Comparison of the gut microbiota composition at the phylum level between patients with insomnia and healthy volunteers. IS — insomnia, CG — control group
Fig. 2. Comparison of the gut microbiota composition at the genus level between patients with insomnia and healthy volunteers. IS — insomnia CG — control group
Table 1. Characteristics of the participants with and without insomnia
Note: * — p < 0.001 relative to CG, ISI — Insomnia Severity Index.
Table 2. Inflammation and endocrine markers in patients with insomnia and healthy volunteers (mean ± SD)
