ISSN Print 2500–1094
ISSN Online 2542–1204
Bulletin of RSMU
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Changes in gut microbiota composition and their associations with cortisol, melatonin and interleukin 6 in patients with chronic insomnia
About authors
V.I. Vernadsky Crimean Federal University, Simferopol, Russia
Correspondence should be addressed: Lesya Nikolaevna Gumenyuk
Lenin boulevard, 5/7, Simferopol, Republic of Crimea, 295006; ur.liam@kuynemyg_aysel
About paper
Author contribution: Masyutina AA, Fatovenko YuV collected, analyzed and interpreted the obtained data; Gumenyuk LN proposed the concept and design for the study; Sorokina LE, Bayramova SS, Alekseenko AA performed statistical analysis; Shavrov YuV, Romanova AA, Seydametova DI wrote the manuscript.
Compliance with ethical standards: the study was approved by the Ethics Committee of Georgievsky Medical Academy (Protocol № 10 dated November 16, 2020) and complied with the Declaration of Helsinki. Voluntary informed consent was obtained from all study participants.
Received: 2021-03-07
Accepted: 2021-04-14
Published online: 2021-04-27
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Fig. 1. Comparison of the gut microbiota composition at the phylum level between patients with insomnia and healthy volunteers. IS — insomnia, CG — control group
Fig. 2. Comparison of the gut microbiota composition at the genus level between patients with insomnia and healthy volunteers. IS — insomnia CG — control group
Table 1. Characteristics of the participants with and without insomnia
Note: * — p < 0.001 relative to CG, ISI — Insomnia Severity Index.
Table 2. Inflammation and endocrine markers in patients with insomnia and healthy volunteers (mean ± SD)
