2021 / 02

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DOI: 10.24075/brsmu.2021.017

ORIGINAL RESEARCH

Changes in gut microbiota composition and their associations with cortisol, melatonin and interleukin 6 in patients with chronic insomnia

Masyutina AA, Gumenyuk LN, Fatovenko YuV, Sorokina LE, Bayramova SS, Alekseenko AI, Shavrov YuV, Romanova AA, Seydametova DI
About authors

V.I. Vernadsky Crimean Federal University, Simferopol, Russia

Correspondence should be addressed: Lesya N. Gumenyuk
Lenin boulevard, 5/7, Simferopol, Republic of Crimea, 295006; ur.liam@kuynemyg_aysel

About paper

Author contribution: Masyutina AA, Fatovenko YuV collected, analyzed and interpreted the obtained data; Gumenyuk LN proposed the concept and design for the study; Sorokina LE, Bayramova SS, Alekseenko AA performed statistical analysis; Shavrov YuV, Romanova AA, Seydametova DI wrote the manuscript.

Compliance with ethical standards: the study was approved by the Ethics Committee of Georgievsky Medical Academy (Protocol № 10 dated November 16, 2020) and complied with the Declaration of Helsinki. Voluntary informed consent was obtained from all study participants.

Received: 2021-03-07 Accepted: 2021-04-14 Published online: 2021-04-27
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  1. Mai E, Buysse DJ. Insomnia: prevalence, impact, pathogenesis, differential diagnosis, and evaluation. Sleep Med Clin. 2008; 3 (2): 167–174. DOI: 10.1016/j.jsmc.2008.02.001.
  2. Ohayon MM. Epidemiology of insomnia: what we know and what we still need to learn. Sleep Med Rev. 2002; 6 (2): 97–111. DOI: 10.1053/smrv.2002.0186.
  3. Levenson JC, Kay DB, Buysse DJ. The pathophysiology of insomnia. Chest, 2015, 147: 1179–1192. DOI: 10.1378/ chest.14-1617.
  4. Rodenbeck A, Hajak G. Neuroendocrine dysregulation in primary insomnia. Rev Neurol (Paris). 2001; 157 (11 Pt 2): S57–61.
  5. Forrest CM, Mackay GM, Stoy N, Stone TW, Darlington LG. Inflammatory status and kynurenine metabolism in rheumatoid arthritis treated with melatonin. Br J Clin Pharmacol. 2007; 64 (4): 517–26. DOI: 10.1111/j.1365-2125.2007.02911.x.
  6. Hurtado-Alvarado G, Dominguez-Salazar E, Pavon L, VelazquezMoctezuma J, Gomez-Gonzalez B. Blood-brain barrier disruption induced by chronic sleep loss: low-grade inflammation may be the link. JImmunolRes. 2016; 2016 (4576012): 1–15. DOI: 10.1155/2016/4576012.
  7. Cryan JF, Dinan TG. Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci. 2012; 13 (10): 701–712. DOI: 10.1038/nrn3346.
  8. Macpherson AJ, Harris NL. Interactions between commensal intestinal bacteria and the immune system. Nat Rev Immunol. 2004; 4 (6): 478–85. DOI: 10.1038/nri1373.
  9. Thaiss CA, Levy M, Korem T. Microbiota diurnal rhythmicity programs host transcriptome oscillations. Cell. 2016; 167 (6): 1495–510.e12. DOI: 10.1016/j.cell.2016.11.003.
  10. Reynolds AC, Paterson JL, Ferguson SA, Stanley D, Wright KP Jr, Dawson D. The shift work and health research agenda: considering changes in gut microbiota as a pathway linking shift work, sleep loss and circadian misalignment, and metabolic disease. Sleep Med Rev. 2017; 34: 3–9. DOI: 10.1016/j.smrv.2016.06.009.
  11. Jackson ML, Butt H, Ball M, Lewis DP, Bruck D. Sleep quality and the treatment of intestinal microbiota imbalance in chronic fatigue syndrome: a pilot study. Sleep Sci. 2015; 8 (3): 124–33. DOI: 10.1016/j.slsci.2015.10.001.
  12. Poroyko V, Carreras A, Khalyfa A, et al. Chronic Sleep Disruption Alters Gut Microbiota, Induces Systemic and Adipose Tissue Inflammation and Insulin Resistance in Mice. Sci Rep. 2016; 6: 35405. DOI: 10.1038/srep35405.
  13. Smith RP, Easson C, Lyle SM, et al. Gut microbiome diversity is associated with sleep physiology in humans. PLoS ONE. 2019; 14 (10): e0222394. Available from: https://doi.org/10.1371/ journal. pone.0222394/
  14. Li Y, Zhang B, Zhou Y, Wang D, et al. Gut Microbiota Changes and Their Relationship with Inflammation in Patients with Acute and Chronic Insomnia. Nat Sci Sleep. 2020; 12: 895–905. Available from: https://doi.org/10.2147/NSS.S271927.
  15. American Academy of Sleep Medicine. International classification of sleep disorders: Diagnostic and coding manual. Westchester, Ill.: American Academy of Sleep Medicine, 2014.
  16. Buysse DJ, Reynolds CF, Monk TH, et al. The Pittsburgh sleep quality index: a new instrument for psychiatric practice and research. Psychiat Res. 1989; 28: 193–213.
  17. Mitra S, Forster-Fromme K, Damms-Machado A, et al. Analysis of the intestinal microbiota using SOLiD16S rRNA gene sequencing and SOLiD shotgun sequencing. BMC Genomics. 2013; 14 (5): 16.
  18. Caporaso JG, Kuczynski J, Stombaugh J, et al. QIIME allows analysis of high-throughput community sequencing data. Nat Methods. 2010; 7 (5): 335–36. DOI: 10.1038/ nmeth.f.303.
  19. DeSantis, TZ, Hugenholtz P, Larsen N. Greengenes, a chimerachecked 16S rRNA gene database and workbench compatible with ARB. Appl Environ Microbiol. 2006; 72: 5069–72.
  20. Ritari J, Salojärvi J, Lahti L, de Vos WM. Improved taxonomic assignment of human intestinal 16S rRNA sequences by a dedicated reference database. BMC Genomics. 2015; 16 (1): 1056. DOI: 10.1186/s12864-015-2265-y.
  21. Mayer EA. Gut feelings: the emerging biology of gut-brain communication. Nat Rev Neurosci. 2011; 12 (8): 453–66. DOI: 10.1038/nrn3071.
  22. Lima-Ojeda JM, Rupprecht R, Baghai TC. «I am I and my bacterial circumstances»: linking gut microbiome, neurodevelopment, and depression. Front Psychiatry. 2017; 8: 153. DOI: 10.3389/ fpsyt.2017.00153.
  23. Vuong HE, Yano JM, Fung TC, Hsiao EY. The microbiome and host behavior. Annu Rev Neurosci. 2017; 40: 21–49. DOI: 10.1146/annurev-neuro-072116-031347.
  24. Liu B, Lin W, Chen S, et al. Gut Microbiota as a subjective measurement for auxiliary diagnosis of insomnia disorder. Front Microbiol. 2019; 10: 1770. DOI: 10.3389/fmicb.2019.01770.
  25. Kim MH, Kang SG, Park JH, Yanagisawa M, Kim CH. Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice. Gastroenterology. 2013; 145 (2): 396–406. DOI: 10.1053/j.gastro.2013.04.056.
  26. Kim CH, Park J, Kim M. Gut microbiota-derived short-chain fatty acids, T cells, and inflammation. Immune Netw. 2014; 14 (6): 277–88. DOI: 10.4110/in.2014.14.6.277.
  27. Mezzatesta ML, Gona F, Stefani S. Enterobacter cloacae complex: clinical impact and emerging antibiotic resistance. Future Microbiol. 2012; 7: 887–902. DOI: 10.2217/fmb.12.61.
  28. Chen CQ, Fichna J, Bashashati M, Li YY, Storr M. Distribution, function and physiological role of melatonin in the lower gut. World J Gastroenterol. 2011; 17: 3888–98. DOI: 10.3748/wjg. v17.i34.3888.
  29. Park YS, Kim SH, Park JW, et al. Melatonin in the colon modulates intestinal microbiota in response to stress and sleep deprivation. Intest Res. 2020; 18 (3): 325–36. DOI: 10.5217/ir.2019.00093.
  30. Zielinski MR, Kim Y, Karpova SA, McCarley RW, Strecker RE, Gerashchenko D. Chronic sleep restriction elevates brain interleukin-1 beta and tumor necrosis factor-alpha and attenuates brain-derived neurotrophic factor expression. Neurosci Lett. 2014; 580: 27–31. DOI: 10.1016/j.neulet.2014.07.04.
  31. Patel SR, Zhu X, Storfer-Isser A, et al. Sleep duration and biomarkers of inflammation. Sleep. 2009; 32 (2): 200–4. DOI: 10.1093/sleep/32.2.200.
  32. Juste C, Kreil DP, Beauvallet C, et al. Bacterial protein signals are associated with Crohn’s disease. Gut. 2014; 63 (10): 1566–77. DOI: 10.1136/gutjnl-2012-303786.
  33. Zhang J, Guo Z, Xue Z, et al. A phylo-functional core of gut microbiota in healthy young Chinese cohorts across lifestyles, geography and ethnicities. ISME J. 2015; 9 (9): 1979–90. DOI: 10.1038/ismej.2015.11.