2021 / 03

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DOI: 10.24075/brsmu.2021.023

ORIGINAL RESEARCH

CDKN2B-AS1 gene polymorphism is associated with primary open-angle glaucoma in women of the Central Black Earth Region, Russia

Eliseeva NV, Ponomarenko IV, Churnosov MI
About authors

Belgorod State National Research University, Belgorod, Russia

Correspondence should be addressed: Mikhail I. Churnosov
Pobedy St., 85, Belgorod, 308015; ur.ude.usb@vosonruhc

About paper

Author contribution: Eliseeva NV — sample design, molecular genetic testing, manuscript writing; Ponomarenko IV — molecular genetic testing, statistical analysis, manuscript writing; Churnosov MI — study concept, manuscript editing; the final version of the manuscript was read and approved by all authors.

Compliance with ethical standards: the study was approved by the Ethics Committee of the Institute of Medicine of the Belgorod State University (protocol № 4 dated May 19, 2015); the informed consent to participation was submitted by all study participants.

Received: 2021-04-21 Accepted: 2021-05-24 Published online: 2021-05-28
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Fig. Linkage disequilibrium patterns between CDKN2B-AS1 (9p21.3) gene polymorphisms in POAG patients (А–B) and controls (C–D) Note: cells in figures on the left contain Lewontin’s standardized disequilibrium coefficient D´-values (D´ =1 corresponds to empty cell). Cell color reflects the degree of generic linkage between polymorphisms: red – tight linkage (D´ = 1; LOD > 2); pink – significant linkage (D´ < 1; LOD > 2); white — weak linkage (D´ < 1; LOD < 2). Haplotype blocks are marked by black lines. Cells in figures on the right contain Pearson correlation coefficient values (r2 )
Table 1. Biomedical and clinical anamnestic characteristics of the studied groups
Table 2. Distribution of CDKN2B-AS1 gene polymorphic loci in POAG patients and female controls
Table 3. Association of CDKN2B-AS1 gene polymorphism with POAG in women
Note: Results were obtained using the logistic regression model; OR — odds ratio, 95% CI — 95% confidence interval (lower and upper bound of 95% CI); p — significance level.
Table 4. Association of CDKN2B-AS1 gene polymorphic loci rs1063192–rs7865618–rs2157719 haplotypes with POAG in women
Note: Results were obtained using the logistic regression model; OR — odds ratio; p — significance level