ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Changes in blood levels of IL1 family cytokines in patients with essential hypertension after having COVID-19
About authors
1 National Research Mordovia State University, Saransk, Russia
2 State Research Institute of Highly Pure Biopreparations, FMBA, St. Petersburg, Russia
Correspondence should be addressed: Olga A. Radaeva
Ulyanova, 26а, Saransk, 430020; ur.liam@demaveadar
About paper
Author contribution: Radaeva ОА — study design, analysis of the results, manuscript editing; Simbirtsev АS — formulating research aim, final version of the article; Kostina YuA — laboratory tests, manuscript editing; Iskandyarova МS — literature analysis, working on the first manuscript draft; Mashnina SV — literature analysis, monitoring of patients; Bessheynov DD — statistical data processing; Negodnova EV — working on the first manuscript draft; Kulyapkin VV — statistical processing of data obtained during the 6th month of follow-up.
Compliance with ethical standards: the study was approved by the Ethics Committee of the National Research Mordovia State University (protocol № 12 dated December 14, 2008, protocol № 85 dated May 27, 2020), the research was carried out in accordance with the WMA Declaration of Helsinki (2013) and the protocol of the Convention on Human Rights and Biomedicine (1999) taking into consideration the Additional Protocol to the Convention on Human Rights and Biomedicine, concerning Biomedical Research (2005). Informed consent was submitted by all patients.
Received: 2021-05-19
Accepted: 2021-06-02
Published online: 2021-06-07
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Table 1. Comparison of serum cytokine levels (pg/mL) in patients with stage 2 EAH prior to COVID-19 and 10, 30, and 180 days after recovery (Ме [Q25–Q75])
Note: * — significance level р < 0.001, ^ — р < 0.01, ' — р < 0.05 (the Wilcoxon test was used for related samples, and the Mann–Whitney U-Test was used for independent samples).
Table 2. Comparison of serum cytokine levels (pg/mL) in patients with no stage 2 EAH prior to COVID-19 and 10, 30, and 180 days after recovery (Ме [Q25–Q75])
Note: * — significance level р < 0.001, ^ — р < 0.01, ' — р < 0.05 (the Wilcoxon test was used for related samples, and the Mann–Whitney U-Test was used for independent samples)
