2021 / 03

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DOI: 10.24075/brsmu.2021.029

REVIEW

Persistence of SARS-CoV-2 in deceased patients and safe handling of infected bodies

Schegolev AI1,2, Tumanova UN1
About authors

1 Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia

2 Pirogov Russian National Research Medical University, Moscow, Russia

Correspondence should be addressed: Alexandr I. Shchegolev
Akademika Oparina, 4, Moscow, 117485; moc.liamg@777natap

About paper

Author contribution: Shchegolev AI designed the study, searched and analyzed the literature and wrote the manuscript; Tumanova UN searched and analyzed the literature and wrote the manuscript.

Received: 2021-05-31 Accepted: 2021-06-14 Published online: 2021-06-18
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  1. Matta S, Chopra KK, Arora VK. Morbidity and mortality trends of Covid 19 in top 10 countries. Indian J Tuberc. 2020; 67 (4S): S167–S172.
  2. Publichnyj dashbord Yandex DataLens. Available from: https://datalens.yandex/7o7is1q6ikh23?tab=0Ze&utm_ source=cbmain&state=7e29b15887.
  3. Sekhawat V, Green A, Mahadeva U. COVID-19 autopsies: conclusions from international studies. Diagn Histopathol (Oxf). 2021; 27 (3): 103–7.
  4. Aubert AC, Lampurlanés XS. Servicios funerarios: exposición laboral a agentes biológicos. Notas Técnicas de Prevenció. 2010; 858: 1–6.
  5. Sterling TR, Pope DS, Bishai WR, Harrington S, Gershon RR, Chaisson RE. Transmission of mycobacterium tuberculosis from a cadaver to an embalmer. N Engl J Med. 2000; 342 (4): 246–8.
  6. Gershon RR, Vlahov D, Escamilla-Cejudo JA, Badawi M, McDiarmid M, Karkashian C. et al. Tuberculosis risk in funeral home employees. J Occup Environ Med. 1998; 40 (5): 497–503.
  7. Nyberg M, Suni J, Haltia M. Isolation of human immunodeficiency virus infection in health care workers. Arch Intern Med. 1990; 153: 1451–8.
  8. Douceron H, Deforges L, Gherardi R, Sobel A, Chariot P. Longlasting postmortem viability of human immunodeficiency virus: A potential risk in forensic medicine practice. Forensic Sci Int. 1993; 60 (1–2): 61–6.
  9. Instrukcii o protivojepidemicheskom rezhime raboty s materialom, zarazhennym ili podozritel'nym na zarazhennost' vozbuditeljami chumy, holery, sapa, melioidoza, natural'noj ospy, sibirskoj jazvy, tuljaremii i brucelleza, Ministerstvo zdravoohranenija SSSR. AlmaAta, 1975.
  10. Federal'nyj zakon "Ob osnovah ohrany zdorov'ja grazhdan v Rossijskoj Federacii" ot 21.11.2011 N 323-FZ.
  11. Teresiński G, Jurek T. Recommendations of the polish society of forensic medicine and criminology and national consultant for forensic medicine with regard to performing forensic post-mortem examinations in case of confirmed COVID-19 disease and suspected SARS CoV-2 infections. Arch Med Sadowej Kryminol. 2019; 69 (4): 147–57.
  12. Sapino A, Facchetti F, Bonoldi E, Gianatti A, Barbareschi M, Società Italiana di Anatomia Patologica e Citologia — SIAPEC. The autopsy debate during the COVID-19 emergency: the Italian experience. Virchows Arch. 2020; 476 (6): 821–3,
  13. Tian S, Xiong Y, Liu H, Niu L, Guo J, Liao M, et al. Pathological study of the 2019 novel coronavirus disease (COVID-19) through postmortem core biopsies. Mod Pathol. 2020; 33 (6): 1007–14.
  14. Moretti M, Malhotra A, Visonà SD, Finley SJ, Osculati AMM, Javan GT. The roles of medical examiners in the COVID-19 era: a comparison between the United States and Italy. Forensic Sci Med Pathol. 2021; 17 (2): 262–70.
  15. Sperhake JP. Autopsies of COVID-19 deceased? Absolutely! Leg Med (Tokyo). 2020; 47: 101769.
  16. Zhu N, Zhang D,Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020; 382 (8): 727–33.
  17. He F, Deng Y, Li W. Coronavirus disease 2019: What we know? J Med Virol. 2020; 92 (7): 719–25.
  18. Wrapp D, Wang N, Corbett KS, Goldsmith JA, Hsieh CL, Abiona O, et al. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science. 2020; 367 (6483): 1260–3.
  19. Xu H, Zhong L, Deng J, Peng J, Dan H, Zeng X, et al. High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. Int J Oral Sci. 2020; 12 (1): 8.
  20. Zou X, Chen K, Zou J, Han P, Hao J, Han Z. Single-cell RNAseq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection. Front Med. 2020; 14 (2): 185–92.
  21. Tang JW, To KF, Lo AW, Sung JJ, Ng HK, Chan PK. Quantitative temporal-spatial distribution of severe acute respiratory syndrome-associated coronavirus (SARSCoV) in post-mortem tissues. J Med Virol. 2007; 79 (9): 1245–53.
  22. Aquila I, Ricci P, Bonetta CF, Sacco MA, Longhini F, Torti C, et al. Analysis of the persistence time of the SARS-CoV-2 virus in the cadaver and the risk of passing infection to autopsy staff. Med Leg J. 2021; 89 (1): 40–53.
  23. Heinrich F, Meißner K, Langenwalder F, Püschel K, Nörz D, Hoffmann A, et al. Postmortem stability of SARS-CoV-2 in nasopharyngeal mucosa. Emerg Infect Dis. 2021; 27 (1): 329–31.
  24. Plenzig S, Bojkova D, Held H, Berger A, Holz F, Cinatl J, et al. Infectivity of deceased COVID-19 patients. Int J Legal Med. 2021 Mar 5; 1–6.
  25. Bogdanović M, Skadrić I, Atanasijević T, Stojković O, Popović V, Savić S, et al. Case Report: Post-mortem histopathological and molecular analyses of the very first documented COVID-19related death in Europe. Front Med. 2021; 8: 612758.
  26. Beltempo P, Curti SM, Maserati R, Gherardi M, Castelli M. Persistence of SARS-CoV-2 RNA in post-mortem swab 35 days after death: A case report. Forensic Sci Int. 2021; 319: 110653.
  27. Sukhikh G, Petrova U, Prikhodko A, Starodubtseva N, Chingin K, Chen H, et al. Vertical transmission of SARS-CoV-2 in second trimester associated with severe neonatal pathology. Viruses. 2021; 13: 447.
  28. Kampf G, Todt D, Pfaender S, Steinmann E. Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents. J Hosp Infect. 2020; 104 (3): 246–51.
  29. van Doremalen N, Bushmaker T, Morris DH, Holbrook MG, Gamble A, Williamson BN, et al. Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1. N Eng J Med. 2020; 382 (16): 1564–7.
  30. Leah FM, Plucinski MM, Marston BJ, Kurbatova EV, Knust B, Murray EL, et al. Public health responses to COVID-19 outbreaks on cruise ships — worldwide, February–March 2020. MMWR Morb Mortal Wkly Rep. 2020; 69 (12): 347–52.
  31. Ansari SA, Springthorpe VS, Sattar SA, Rivard S, Rahman M. Potential role of hands in the spread of respiratory viral infections: studies with human parainfluenza virus 3 and rhinovirus 14. J Clin Microbiol. 1991; 29 (10): 2115–9.
  32. Cevik M, Tate M, Lloyd O, Maraolo AE, Schafers J, Ho A. SARSCoV-2, SARS-CoV, and MERS-CoV viral load dynamics, duration of viral shedding, and infectiousness: a systematic review and meta-analysis. Lancet Microbe. 2021; 2: e13–22.
  33. Davis GG, Williamson AK. Risk of Coronavirus Disease 2019 transmission during autopsy. Arch Pathol Lab Med. 2020; 144 (12): 1445a–1445.
  34. Nakamura M, Tojo M, Takaso M, Hitosugi M. A regional approach for infection prevention in death investigations during the COVID-19 era. Leg Med (Tokyo). 2021; 48: 101829.
  35. Centre for Health Protection. Precautions for Handling and Disposal of Dead Bodies, Hong Kong, China, 2020. Available from: https://www.chp.gov.hk/files/pdf/grp-guideline-hp-icprecautions_for_handling_and_disposal_of_dead_bodies_en.pdf.
  36. Government of India Ministry of Health & Family Welfare Directorate General of Health Services. COVID-19: Guidelines on dead body management, India, 2020. Available from: https://www.mohfw. gov.in/pdf/1584423700568_COVID19GuidelinesonDeadbodyma nagement.pdf.
  37. Centers for Disease Control and Prevention. Collection and Submission of Postmortem Specimens from Deceased Persons with Known or Suspected COVID-19 (Postmortem Guidance). Available from: https://www.cdc.gov/coronavirus/2019-ncov/ hcp/guidance-postmortem-specimens.html.
  38. Rijksinstituut voor Volksgezondheid en Milieu. COVID-19 richtlijn (guideline). Available from: https://lci.rivm.nl/richtlijnen/covid-19.
  39. Health and Safety Executive. Managing infection risks when handling the deceased. Guidance for the mortuary, post-mortem room and funeral premises, and during exhumation. Available from: https://www.hse.gov.uk/pUbns/priced/hsg283.pdf.
  40. European Centre for Disease Prevention and Control. Considerations related to the safe handling of bodies of deceased persons with suspected or confirmed COVID-19, Europe, 2020. Available from: https://www.ecdc.europa.eu/en/publications-data/ considerations-related-safe-handling-bodies-deceased-personssuspected-or.
  41. WHO Guidelines. Infection prevention and control of epidemic- and pandemic-prone acute respiratory infections in health care — WHO Guidelines. Available from: https://apps.who.int/iris/bitstream/ha ndle/10665/112656/9789241507134_eng.pdf?sequence=1.
  42. Keten D, Okdemir E, Keten A. Precautions in postmortem examinations in Covid-19 — Related deaths: Recommendations from Germany. J Forensic Leg Med. 2020; 73: 102000.
  43. Frank GA, Kovalev AV, Gribunov YuP, Zaslavskij GI, Kildjushov EM, Jagmurov OD, i dr. Issledovanie umershih s podozreniem na koronavirusnuju infekciju (COVID-19). V sbornike: Vremennye metodicheskie rekomendacii. Versija 22 (23.07.2020). M., 2020; 428 s. Russian.
  44. Vremennye metodicheskie rekomendacii: profilaktika, diagnostika i lechenie novoj koronavirusnoj infekcii (COVID-19). Versija 10 (08.02.2021). M., 2021; 262 s. Russian.
  45. Zajratyanc OV, Kanibolockij AA, Mihaleva LM, Mishnev OD, Savelov NS, Avdalyan AM, i dr. Novaja koronavirusnaja infekcija (COVID-19). Organizacija raboty patologoanatomicheskoj sluzhby. V sbornike: Vremennye metodicheskie rekomendacii. Versija 3 (15.11.2020). M., 2020; 36 s. Russian.
  46. Hanley B, Lucas SB, Youd E, Swift B, Osborn M. Autopsy in suspected COVID-19 cases. J Clin Pathol. 2020; 73: 239–42.
  47. Monteiro RAA, Duarte-Neto AN, Silva LFFD, Oliveira EP, Filho JT, Santos GABD, et al. Ultrasound-guided minimally invasive autopsies: A protocol for the study of pulmonary and systemic involvement of COVID-19. Clinics (Sao Paulo). 2020; 75: e1972.
  48. Roberts IS, Benamore RE, Benbow EW, Lee SH, Harris JN, Jackson A, et al. Post-mortem imaging as an alternative to autopsy in the diagnosis of adult deaths: a validation study. Lancet. 2012; 379 (9811): 136–42.
  49. Kniep I, Lutter M, Ron A, Edler C, Püschel K, Ittrich H, et al. Postmortem imaging of the lung in cases of COVID-19 deaths. Radiologe. 2020; 60 (10): 927–33.
  50. Tumanova UN, Lyapin VM, Bychenko VG, Shchegolev AI, Sukhikh GT. Posmertnaja MRT dlja diagnostiki vrozhdennoj pnevmonii. Vestnik Rossijskogo gosudarstvennogo medicinskogo universiteta. 2016; 4: 48–55. Russian.
  51. Tumanova UN, Shchegolev AI. Vozmozhnosti i ogranichenija virtual'noj autopsii v neonatologii. REJR. 2017; 7 (1): 20–33. Russian.
  52. Kanchan T, Shrestha R, Krishan K. Post-mortem ultrasonography: a safer alternative to autopsies in COVID-19 deaths. J Ultrasound. 2020 Oct 31; 1–2.