2021 / 05

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DOI: 10.24075/brsmu.2021.044

ORIGINAL RESEARCH

Predictive potential of macrophage population phenotyping in malignization of H. pylori-associated chronic gastritis

Golubinskaya EP1, Sataieva TP1, Fomochkina II1, Kubyshkin AV1, Makalish TP1, Shkolyar NA2, Galyshevskaya AA1, Varghese DV1
About authors

1 V.I. Vernadsky Crimean Federal University, Simferopol, Russia

2 Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia

Correspondence should be addressed: Tatiana P. Sataieva
Bulvar Lenina, 5/7, Simferopol, 295006; ur.liam@loocznat

About paper

Funding: the study was carried out within the framework of the Government Assignment № FZEG-2020-0060 of the Ministry of Science and Higher Education of the Russian Federation in the field of scientific research “Algorithms for molecular genetic diagnosis of malignant neoplasms and approaches to their targeted therapy using cellular and genetic technologies”.

Author contribution: Golubinskaya EP — clinical data analysis, immunohistochemistry, manuscript editing; Sataieva TP, Fomochkina II — systematic analysis, manuscript writing; Kubyshkin AV — statistical analysis, manuscript editing; Makalish TP — sample preparation for morphological assessment, immunohistochemistry; Shkolyar NA — biopsy sample collection and preparation; Galyshevskaya AA, Varghese DV — morphometric data processing.

Compliance with ethical standards: the study was approved by the Ethics Committee of the Medical Academy named after S. I. Georgievsky (protocol № 15 dated December 5, 2020); the study was conducted in accordance with the Declaration of Helsinki 1964 (revised in 1975 and 1983), Good Clinical Practice (GCP) standards and the Federal Law № 323-FZ “On the Basics of Protecting the Health of Citizens in the Russian Federation” dated November 21, 2011. The informed consent was submitted by all patients.

Received: 2021-08-19 Accepted: 2021-08-03 Published online: 2021-09-14
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