2021 / 06

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DOI: 10.24075/brsmu.2021.054

ORIGINAL RESEARCH

Ultrasound imaging of vagus nerves in patients with Parkinson's disease

Chechetkin AO, Moskalenko AN, Fedotova EYu, Illarioshkin SN
About authors

Research Center of Neurology, Moscow, Russia

Correspondence should be addressed: Andrey О. Chechetkin
Volokolamskoe shosse, 80, Moscow, 125367, Russia; moc.liamg@niktehcehcyerdna

About paper

Author contribution: Chechetkin AO — study design, acquisition of ultrasound imaging data, data interpretation, manuscript preparation; Moskalenko AN — clinical data acquisition, analysis and interpretation; Fedotova EYu, Illarioshkin SN — study design, manuscript editing.

Compliance with ethical standards: the study was approved by the Ethics Committee of the Research Center of Neurology (Protocol No. 2-6/20 dated March 18, 2020)

Received: 2021-10-25 Accepted: 2021-11-11 Published online: 2021-11-24
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  1. Poewe W, Seppi K, Tanner CM, Halliday GM, Brundin P, Volkmann J, et al. Parkinson disease. Nat Rev Dis Primers. 2017; 3 (1): 1–21. DOI: 10.1038/nrdp.2017.13.
  2. Klingelhoefer L, Reichmann H. Pathogenesis of Parkinson disease–the gutbrain axis and environmental factors. Nat Rev Neurol. 2015. 11; 625–36. DOI: 10.1038/nrneurol.2015.197.
  3. Hawkes CH, Del Tredici K, Braak H. Parkinson’s disease: a dualhit hypothesis. Neuropathol Appl Neurobiol. 2007; 33: 599–614. DOI: 10.1111/j.1365-2990.2007.00874.x.
  4. Horsager J, Walter U, Fedorova TD, Andersen KB, Skjærbæk C, Knudsen K, et al. Vagus Nerve Cross-Sectional Area in Patients With Parkinson's Disease-An Ultrasound CaseControl Study. Front Neurol. 2021; 12: 681413. DOI: 10.3389/ fneur.2021.681413.
  5. Del Tredici K, Braak H. Review: Sporadic Parkinson’s disease: development and distribution of α-synuclein pathology. Neuropathol Appl Neurobiol. 2016; 42: 33–50. DOI: 10.1111/ nan.12298.
  6. Svensson E, Horváth-Puhó E, Thomsen RW, Djurhuus JC, Pedersen L, Borghammer P, et al. Vagotomy and subsequent risk of Parkinson’s disease. Ann Neurol. 2015; 78: 522–29. DOI: 10.1002/ana.24448.
  7. Liu B, Fang F, Pedersen NL, Tillander A, Ludvigsson JF, Ekbom A, et al. Vagotomy and Parkinson disease: a Swedish register-based matchedcohort study. Neurology. 2017; 88: 1996–2002. DOI: 10.1212/WNL.0000000000 003961.
  8. Holmqvist S, Chutna O, Bousset L, Aldrin-Kirk P, Li W, Björklund T., et al. Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats. Acta Neuropathol. 2014; 128: 805–20. DOI: 10.1007/s00401-014-1343-6.
  9. Mu L, Sobotka S, Chen J, Su H, Sanders I, Adler C, et al. Alphasynuclein pathology and axonal degeneration of the peripheral motor nerves innervating pharyngeal muscles in Parkinson disease. J Neuropathol Exp Neurol. 2013. 72; 119–29. DOI: 10.1097/NEN.0b013e3182 801cde.
  10. Nakamura K, Mori F, Tanji K, Miki Y, Toyoshima Y, Kakita A, et al. α-Synuclein pathology in the cranial and spinal nerves in Lewy body disease. Neuropathology. 2016; 36: 262–69. DOI: 10.1111/ neup. 12269.
  11. Gjerloff T, Fedorova T, Knudsen K, Munk O, Nahimi A, Jacobsen S, et al. Imaging acetylcholinesterase density in peripheral organs in Parkinson’s disease with 11C-donepezil PET. Brain. 2015; 138 (Pt 3): 653–63. DOI: 10.1093/brain/awu369.
  12. Fedorova T, Seidelin L, Knudsen K, Schacht A, Geday J, Pavese N, et al. Decreased intestinal acetylcholinesterase in early Parkinson disease: An (11)C-donepezil PET study. Neurology. 2017. 88: 775–81. DOI: 10.1212/WNL.0000000000003633.
  13. Grimm A, Décard B, Athanasopoulou I, Schweikert K, Sinnreich M, Axer H. Nerve ultrasound for differentiation between amyotrophic lateral sclerosis and multifocal motor neuropathy. J Neurol. 2015; 262: 870–80. DOI: 10.1007/s00415-015-7648-0.
  14. Hong M, Baek J, Kim D, Ha E, Choi W, Choi Y, et al. Spinal accessory nerve: ultrasound findings and correlations with neck lymph node levels. Ultraschall Med. 2016; 37: 487–91. DOI: 10.1055/s-0034-1385673.
  15. Tawfik E, Walker F, Cartwright M, El-Hilaly R. Diagnostic ultrasound of the vagus nerve in patients with diabetes. J Neuroimaging. 2017; 27: 589–93. DOI: 10.1111/jon.12452.
  16. Tsukita K, Taguchi T, Sakamaki-Tsukita H, Tanaka K, Suenaga T. Vagus nerve atrophy in Parkinson’s disease detected by ultrasonography. Journal of the Neurological Sciences. 2017; 365, 129. DOI: 10.1016/j.jns.2017.08.391.
  17. Tsukita K, Taguchi T, Sakamaki-Tsukita H, Tanaka K, Suenaga T. The vagus nerve becomes smaller in patients with Parkinson’s disease: a preliminary cross-sectional study using ultrasonography. Parkinsonism Relat Disord. 2018; 55: 148–49. DOI: 10.1016/j. parkreldis.2018.06.002.
  18. Fedtke N, Witte O, Prell T. Ultrasonography of the vagus nerve in Parkinson’s disease. Front Neurol. 2018; 9: 525. DOI: 10.3389/ fneur.2018.00525.
  19. Walter U, Tsiberidou P, Kersten M, Storch A, Lohle M. Atrophy of the vagus nerve in Parkinson’s Disease revealed by highresolution ultrasonography. Front Neurol. 2018; 9: 805. DOI: 10.3389/fneur.2018.00805.
  20. Pelz J, Belau E, Fricke C, Classen J, Weise D. Axonal degeneration of the vagus nerve in Parkinson’s disease-a high-resolution ultrasound study. Front Neurol. 2018; 9: 951. DOI: 10.3389/ fneur.2018.00951.
  21. Laucius O, Balnyte R, Petrikonis K, Matijosaitis V, Juceviciute N, Vanagas T, et al. Ultrasonography of the vagus nerve in the diagnosis of Parkinson’s disease. Parkinsons Dis. 2020; 2020: 2627471. DOI: 10.1155/2020/2627471.
  22. Sijben L, Mess W, Walter U, Janssen A, Kuijf M, Oosterloo M. The cross-sectional area of the vagus nerve is not reduced in Parkinson’s Disease patients. medRxiv [Preprint]. 2020. DOI: 10.1101/2020.10.19.20214973.
  23. Sartucci F, Bocci T, Santin M, Bongioanni P, Orlandi G. Highresolution ultrasound changes of the vagus nerve in idiopathic Parkinson’s disease (IPD): a possible additional index of disease. Neurol Sci. 2021. DOI: 10.1007/s10072-021-05183-5.
  24. Fedotova EYu, Chechetkin AO, Shadrina MI, Slominsky PA, Ivanova-Smolenskaya IA, Illarioshkin SN. Transcranial sonography in Parkinson’s disease. Zh Nevrol Psikhiatr Im SS Korsakova. 2011; 1: 49–55.
  25. Pelz J, Belau E, Henn P, Hammer N, Classen J, Weise D. Sonographic evaluation of the vagus nerves: protocol, reference values, and side-to-side differences. Muscle Nerve. 2018; 57 (5): 766–71. DOI: 10.1002/mus.25993.
  26. Verlinden T, Rijkers K, Hoogland G, Herrler A. Morphology of the human cervical vagus nerve: implications for vagus nerve stimulation treatment. Acta Neurol Scand. 2016; 133: 173–82. DOI: 10.1111/ane.12462.
  27. Hoffman H, Schnitzlein H. The numbers of nerve fibers in the vagus nerve of man. Anat Rec. 1961; 139: 429–35. DOI: 10.1002/ ar.1091390312.
  28. Cheng Z, Powley T, Schwaber J, Doyle F. Projections of the dorsal motor nucleus of the vagus to cardiac ganglia of rat atria: an anterograde tracing study. J Comp Neurol. 1999; 410: 320–41.
  29. Braak H, Del Tredici K, Rub U, de Vos R, Steur J, Braak E. Staging of brain pathology related to sporadic Parkinson’s disease. Neurobiol Aging. 2003; 24: 197–211. DOI: 10.1016/S01974580(02)00065-9.
  30. Fedotova EYu, Chechetkin AO, Abramycheva NYu, Chigaleychik LA, Baziyan BKh, Ponomareva ТА, et al. Identification of people at the latent stage of Parkinson’s disease (the PARKINLAR study): first results and an optimization of the algorithm. Zh Nevrol Psikhiatr Im S S Korsakova. 2015; 115 (6): 4–11. DOI: 10.17116/ jnevro2015115614-11.