ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
Copyright: © 2021 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
ORIGINAL RESEARCH
Plasma low molecular weight aminothiols in ischemic stroke patients with type 2 diabetes mellitus
About authors
1 Research Center of Neurology, Moscow, Russia
2 Research Institute of General Pathology and Pathophysiology, Moscow, Russia
3 Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia
Correspondence should be addressed: Marina Yu. Maksimova
Volokolamskoe shosse, 80, Moscow, 125367, Russia; ur.liam@avomixamncn
About paper
Author contribution: Maksimova МYu — concept formulation, data synthesis, manuscript writing; Ivanov AV — concept formulation, literature analysis, assessment of low molecular weight aminothiols; Nikiforova KA — primary laboratory data acquisition; Virus ED — laboratory data synthesis; Suanova ЕТ — statistical data processing; Ochtova FR — clinical assessment of patients; Piradov MA — study management; Kubatiev AA — study management.
Compliance with ethical standards: the study was approved by the Ethics Committee of the Research Center of Neurology (protocol № 3-1/16 dated March 16, 2016), it was carried out in accordance with the basic principles outlined in the Declaration of Helsinki.
Received: 2021-10-25
Accepted: 2021-11-13
Published online: 2021-12-09
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Fig. ROC curve for poor functional outcome (mRS ≥ 3) in patients with a combination of IS and T2D when assessing the glutathione redox status Р (%)
Table 1. Characteristics of patients with IS and chronic cerebrovascular disease
Table 2. Comparative analysis of the low molecular weight aminothiols plasma levels (μM) and redox status (%) in patients with IS and controls (Mann–Whitney U test)
Table 3. Characteristics of patients with a combination of IS and T2D, and patients with a combination of IS and stress hyperglycemia (Mann–Whitney U test)
Table 4. Comparison of the low molecular weight aminothiols plasma levels (μM) and redox status (%) in patients with a combination of IS and T2D, and in patients with a combination of IS and stress hyperglycemia (Mann–Whitney U test)
Table 5. Low molecular weight aminothiols plasma levels (μM) and redox status (%) in patients with a combination of IS and T2D taking into account the functional recovery (Mann–Whitney U test)
