2021 / 06

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DOI: 10.24075/brsmu.2021.057

ORIGINAL RESEARCH

Plasma low molecular weight aminothiols in ischemic stroke patients with type 2 diabetes mellitus

Maksimova MYu1, Ivanov AV2, Nikiforova KA2, Virus ED2, Suanova ET3, Ochtova FR3, Piradov MA1, Kubatiev AA2
About authors

1 Research Center of Neurology, Moscow, Russia

2 Research Institute of General Pathology and Pathophysiology, Moscow, Russia

3 Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia

Correspondence should be addressed: Marina Yu. Maksimova
Volokolamskoe shosse, 80, Moscow, 125367, Russia; ur.liam@avomixamncn

About paper

Author contribution: Maksimova МYu — concept formulation, data synthesis, manuscript writing; Ivanov AV — concept formulation, literature analysis, assessment of low molecular weight aminothiols; Nikiforova KA — primary laboratory data acquisition; Virus ED — laboratory data synthesis; Suanova ЕТ — statistical data processing; Ochtova FR — clinical assessment of patients; Piradov MA — study management; Kubatiev AA — study management.

Compliance with ethical standards: the study was approved by the Ethics Committee of the Research Center of Neurology (protocol № 3-1/16 dated March 16, 2016), it was carried out in accordance with the basic principles outlined in the Declaration of Helsinki.

Received: 2021-10-25 Accepted: 2021-11-13 Published online: 2021-12-09
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Fig. ROC curve for poor functional outcome (mRS ≥ 3) in patients with a combination of IS and T2D when assessing the glutathione redox status Р (%)
Table 1. Characteristics of patients with IS and chronic cerebrovascular disease
Table 2. Comparative analysis of the low molecular weight aminothiols plasma levels (μM) and redox status (%) in patients with IS and controls (Mann–Whitney U test)
Table 3. Characteristics of patients with a combination of IS and T2D, and patients with a combination of IS and stress hyperglycemia (Mann–Whitney U test)
Table 4. Comparison of the low molecular weight aminothiols plasma levels (μM) and redox status (%) in patients with a combination of IS and T2D, and in patients with a combination of IS and stress hyperglycemia (Mann–Whitney U test)
Table 5. Low molecular weight aminothiols plasma levels (μM) and redox status (%) in patients with a combination of IS and T2D taking into account the functional recovery (Mann–Whitney U test)