2021 / 06

Next Paper
DOI: 10.24075/brsmu.2021.057
Copyright: © 2021 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).

ORIGINAL RESEARCH

Plasma low molecular weight aminothiols in ischemic stroke patients with type 2 diabetes mellitus

Maksimova MYu1, Ivanov AV2, Nikiforova KA2, Virus ED2, Suanova ET3, Ochtova FR3, Piradov MA1, Kubatiev AA2
About authors

1 Research Center of Neurology, Moscow, Russia

2 Research Institute of General Pathology and Pathophysiology, Moscow, Russia

3 Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia

Correspondence should be addressed: Marina Yu. Maksimova
Volokolamskoe shosse, 80, Moscow, 125367, Russia; ur.liam@avomixamncn

About paper

Author contribution: Maksimova МYu — concept formulation, data synthesis, manuscript writing; Ivanov AV — concept formulation, literature analysis, assessment of low molecular weight aminothiols; Nikiforova KA — primary laboratory data acquisition; Virus ED — laboratory data synthesis; Suanova ЕТ — statistical data processing; Ochtova FR — clinical assessment of patients; Piradov MA — study management; Kubatiev AA — study management.

Compliance with ethical standards: the study was approved by the Ethics Committee of the Research Center of Neurology (protocol № 3-1/16 dated March 16, 2016), it was carried out in accordance with the basic principles outlined in the Declaration of Helsinki.

Received: 2021-10-25 Accepted: 2021-11-13 Published online: 2021-12-09
|
  1. Hill MD Stroke and diabetes mellitus. Handb Clin Neurol. 2014;126:167-74. DOI: 10.1016/B978-0-444-53480-4.00012-6.
  2. Sarwar N, Aspelund T, Eiriksdottir G, Gobin R, Seshasai SR, Forouhi NG, et al. Markers of dysglycaemia and risk of coronary heart disease in people without diabetes: Reykjavik prospective study and systematic review. PLoS Med. 2010; 7 (5): e1000278. DOI: 10.1371/journal.pmed.1000278.
  3. Barth E, Albuszies G, Baumgart K, Matejovic M, Wachter U, Vogt J, et al. Glucose metabolism and catecholamines. Crit Care Med. 2007; 35 (9 Suppl): S508–18. DOI: 10.1097/01. CCM.0000278047.06965.20.
  4. Zhu B, Pan Y, Jing J, Meng X, Zhao X, Liu L, et al. Stress Hyperglycemia and Outcome of Non-diabetic Patients After Acute Ischemic Stroke. Front Neurol. 2019; 10: 1003. DOI: 10.3389/ fneur.2019.01003.
  5. Tuttolomondo A, Pinto A, Salemi G, Di Raimondo D, Di Sciacca R, Fernandez P, et al. Diabetic and non-diabetic subjects with ischemic stroke: differences, subtype distribution and outcome. Nutr Metab Cardiovasc Dis. 2008; 18 (2): 152–7. DOI: 10.1016/j. numecd.2007.02.003.
  6. Zhao H, Han Z, Ji X, Luo Y. Epigenetic regulation of oxidative stress in ischemic stroke. Aging Dis. 2016; 2016; 7 (3): 295–306. DOI: 10.14336/AD.2015.1009.
  7. Khoshnam SE, Winlow W, Farzaneh M, Farbood Y, Moghaddam HF Pathogenic mechanisms following ischemic stroke. Neurol Sci. 2017; 38 (7): 1167–86. DOI: 10.1007/s10072-017-2938-1.
  8. Ivanov AV, Alexandrin VV, Paltsyn AA, Nikiforova KA, Virus ED, Luzyanin BP, et al. Plasma low-molecular-weight thiol/ disulphide homeostasis as an early indicator of global and focal cerebral ischaemia. Redox Rep. 2017; 22 (6): 460–6. DOI: 10.1080/13510002.2017.1311464.
  9. Maksimova MY, Ivanov AV, Virus ED, Alexandrin VV, Nikiforova KA, Bulgakova PO, et al. Disturbance of thiol/disulfide aminothiols homeostasis in patients with acute ischemic stroke stroke: Preliminary findings. Clin Neurol Neurosurg. 2019; 183: 105393. DOI: 10.1016/j.clineuro.2019.105393.
  10. Duman BS, Oztürk M, Yilmazeri S, Hatemi H. Thiols, malonaldehyde and total antioxidant status in the Turkish patients with type 2 diabetes mellitus. Tohoku J Exp Med. 2003; 201 (3): 147–55. DOI: 10.1620/tjem.201.147.
  11. Tessier D, Khalil A, Fülöp T. Effects of an oral glucose challenge on free radicals/antioxidants balance in an older population with type II diabetes. J Gerontol A Biol Sci Med Sci. 1999; 54 (11): M541–5. DOI: 10.1093/gerona/54.11.m541.
  12. Forrester TE, Badaloo V, Bennett FI, Jackson AA. Excessive excretion of 5-oxoproline and decreased levels of blood glutathione in type II diabetes mellitus. Eur J Clin Nutr. 1990; 44 (11): 847–50. PMID: 2086214.
  13. Karolczak K, Kubalczyk P, Głowacki R, Pietruszyński R, Watała C. An inverse relationship between plasma glutathione concentration and fasting glycemia in patients with coronary artery disease and concomitant type 2 diabetes: A pilot study. Adv Clin Exp Med. 2017; 26 (9): 1359–66. DOI: 10.17219/acem/65441.
  14. Lutchmansingh FK, Hsu JW, Bennett FI, Badaloo AV, McFarlaneAnderson N, Gordon-Strachan GM, et al. Glutathione metabolism in type 2 diabetes and its relationship with microvascular complications and glycemia. PLoS One. 2018; 13 (6): e0198626. DOI: 10.1371/journal.pone.0198626.
  15. Fussner J, Velasco C. Stroke Coordinator Boot Camp. Assessing Stroke — Scores and Scales — American Heart Association. Available from: https://www.heart.org.
  16. Quinn TJ, Langhorne P, Stott DJ. Barthel index for stroke trials: development, properties, and application. Stroke. 2011; 42 (4): 1146–51. DOI: 10.1161/STROKEAHA.110.598540.
  17. Harrison JK, McArthur KS, Quinn TJ. Assessment scales in stroke: clinimetric and clinical considerations. Clin Interv Aging. 2013; 8: 201–11. DOI: 10.2147/CIA.S32405.
  18. Adams HP, Bendixen BH, Kappelle LJ, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 1993; 24: 35–41. DOI: 10.1161/01.STR.24.1.35.
  19. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2013; 36: S67–S74. PMID:15618111.
  20. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001; 414 (6865): 813–20. DOI: 10.1038/414813a.
  21. Nishikawa T, Kukidome D, Sonoda K, Fujisawa K, Matsuhisa T, Motoshima H, et al. Impact of mitochondrial ROS production on diabetic vascular complications. Diabetes Res Clin Pract. 2007; 77 Suppl 1: S41–5. DOI: 10.1016/j.diabres.2007.01.031.
  22. Smith CJ, Lawrence CB, Rodriguez-Grande B, Kovacs KJ, Pradillo JM, Denes A. The immune system in stroke: clinical challenges and their translation to experimental research. J Neuroimmune Pharmacol. 2013; 8 (4): 867–87. DOI: 10.1007/ s11481-013-9469-1.
  23. Poulsen RC, Knowles HJ, Carr AJ, Hulley PA. Cell differentiation versus cell death: extracellular glucose is a key determinant of cell fate following oxidative stress exposure. Cell Death Dis. 2014; 5 (2): e1074. DOI: 10.1038/cddis.2014.52.
  24. Stratton IM, Adler AI, Neil HA, Matthews DR, Manley SE, Cull CA, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ. 2000; 321 (7258): 405–12. DOI: 10.1136/bmj.321.7258.405.
  25. Bruno A, Liebeskind D, Hao Q, Raychev R; UCLA Stroke Investigators. Diabetes mellitus, acute hyperglycemia, and ischemic stroke. Curr Treat Options Neurol. 2010; 12 (6): 492–503. DOI: 10.1007/s11940-010-0093-6.
  26. Venkat P, Chopp M, Chen J. Blood-Brain Barrier Disruption, Vascular Impairment, and Ischemia/Reperfusion Damage in Diabetic Stroke. J Am Heart Assoc. 2017; 6 (6): e005819. DOI: 10.1161/JAHA.117.005819.
  27. Jones DP. Redox potential of GSH/GSSG couple: assay and biological significance. Methods Enzymol. 2002; 348: 93–112. DOI: 10.1016/s0076-6879(02)48630-2.
  28. Wu G, Fang YZ, Yang S, Lupton JR, Turner ND. Glutathione metabolism and its implications for health. J Nutr. 2004; 134 (3): 489–92. DOI: 10.1093/jn/134.3.489.
  29. Etemad A, Vasudevan R, Aziz AF, Yusof AK, Khazaei S, Fawzi N, et al. Analysis of selected glutathione S-transferase gene polymorphisms in Malaysian type 2 diabetes mellitus patients with and without cardiovascular disease. Genet Mol Res. 2016; 15 (2). DOI: 10.4238/gmr.15025845.