2021 / 06

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DOI: 10.24075/brsmu.2021.057

ORIGINAL RESEARCH

Plasma low molecular weight aminothiols in ischemic stroke patients with type 2 diabetes mellitus

Maksimova MYu1, Ivanov AV2, Nikiforova KA2, Virus ED2, Suanova ET3, Ochtova FR3, Piradov MA1, Kubatiev AA2
About authors

1 Research Center of Neurology, Moscow, Russia

2 Research Institute of General Pathology and Pathophysiology, Moscow, Russia

3 Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia

Correspondence should be addressed: Marina Yu. Maksimova
Volokolamskoe shosse, 80, Moscow, 125367, Russia; ur.liam@avomixamncn

About paper

Author contribution: Maksimova МYu — concept formulation, data synthesis, manuscript writing; Ivanov AV — concept formulation, literature analysis, assessment of low molecular weight aminothiols; Nikiforova KA — primary laboratory data acquisition; Virus ED — laboratory data synthesis; Suanova ЕТ — statistical data processing; Ochtova FR — clinical assessment of patients; Piradov MA — study management; Kubatiev AA — study management.

Compliance with ethical standards: the study was approved by the Ethics Committee of the Research Center of Neurology (protocol № 3-1/16 dated March 16, 2016), it was carried out in accordance with the basic principles outlined in the Declaration of Helsinki.

Received: 2021-10-25 Accepted: 2021-11-13 Published online: 2021-12-09
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  1. Hill MD Stroke and diabetes mellitus. Handb Clin Neurol. 2014;126:167-74. DOI: 10.1016/B978-0-444-53480-4.00012-6.
  2. Sarwar N, Aspelund T, Eiriksdottir G, Gobin R, Seshasai SR, Forouhi NG, et al. Markers of dysglycaemia and risk of coronary heart disease in people without diabetes: Reykjavik prospective study and systematic review. PLoS Med. 2010; 7 (5): e1000278. DOI: 10.1371/journal.pmed.1000278.
  3. Barth E, Albuszies G, Baumgart K, Matejovic M, Wachter U, Vogt J, et al. Glucose metabolism and catecholamines. Crit Care Med. 2007; 35 (9 Suppl): S508–18. DOI: 10.1097/01. CCM.0000278047.06965.20.
  4. Zhu B, Pan Y, Jing J, Meng X, Zhao X, Liu L, et al. Stress Hyperglycemia and Outcome of Non-diabetic Patients After Acute Ischemic Stroke. Front Neurol. 2019; 10: 1003. DOI: 10.3389/ fneur.2019.01003.
  5. Tuttolomondo A, Pinto A, Salemi G, Di Raimondo D, Di Sciacca R, Fernandez P, et al. Diabetic and non-diabetic subjects with ischemic stroke: differences, subtype distribution and outcome. Nutr Metab Cardiovasc Dis. 2008; 18 (2): 152–7. DOI: 10.1016/j. numecd.2007.02.003.
  6. Zhao H, Han Z, Ji X, Luo Y. Epigenetic regulation of oxidative stress in ischemic stroke. Aging Dis. 2016; 2016; 7 (3): 295–306. DOI: 10.14336/AD.2015.1009.
  7. Khoshnam SE, Winlow W, Farzaneh M, Farbood Y, Moghaddam HF Pathogenic mechanisms following ischemic stroke. Neurol Sci. 2017; 38 (7): 1167–86. DOI: 10.1007/s10072-017-2938-1.
  8. Ivanov AV, Alexandrin VV, Paltsyn AA, Nikiforova KA, Virus ED, Luzyanin BP, et al. Plasma low-molecular-weight thiol/ disulphide homeostasis as an early indicator of global and focal cerebral ischaemia. Redox Rep. 2017; 22 (6): 460–6. DOI: 10.1080/13510002.2017.1311464.
  9. Maksimova MY, Ivanov AV, Virus ED, Alexandrin VV, Nikiforova KA, Bulgakova PO, et al. Disturbance of thiol/disulfide aminothiols homeostasis in patients with acute ischemic stroke stroke: Preliminary findings. Clin Neurol Neurosurg. 2019; 183: 105393. DOI: 10.1016/j.clineuro.2019.105393.
  10. Duman BS, Oztürk M, Yilmazeri S, Hatemi H. Thiols, malonaldehyde and total antioxidant status in the Turkish patients with type 2 diabetes mellitus. Tohoku J Exp Med. 2003; 201 (3): 147–55. DOI: 10.1620/tjem.201.147.
  11. Tessier D, Khalil A, Fülöp T. Effects of an oral glucose challenge on free radicals/antioxidants balance in an older population with type II diabetes. J Gerontol A Biol Sci Med Sci. 1999; 54 (11): M541–5. DOI: 10.1093/gerona/54.11.m541.
  12. Forrester TE, Badaloo V, Bennett FI, Jackson AA. Excessive excretion of 5-oxoproline and decreased levels of blood glutathione in type II diabetes mellitus. Eur J Clin Nutr. 1990; 44 (11): 847–50. PMID: 2086214.
  13. Karolczak K, Kubalczyk P, Głowacki R, Pietruszyński R, Watała C. An inverse relationship between plasma glutathione concentration and fasting glycemia in patients with coronary artery disease and concomitant type 2 diabetes: A pilot study. Adv Clin Exp Med. 2017; 26 (9): 1359–66. DOI: 10.17219/acem/65441.
  14. Lutchmansingh FK, Hsu JW, Bennett FI, Badaloo AV, McFarlaneAnderson N, Gordon-Strachan GM, et al. Glutathione metabolism in type 2 diabetes and its relationship with microvascular complications and glycemia. PLoS One. 2018; 13 (6): e0198626. DOI: 10.1371/journal.pone.0198626.
  15. Fussner J, Velasco C. Stroke Coordinator Boot Camp. Assessing Stroke — Scores and Scales — American Heart Association. Available from: https://www.heart.org.
  16. Quinn TJ, Langhorne P, Stott DJ. Barthel index for stroke trials: development, properties, and application. Stroke. 2011; 42 (4): 1146–51. DOI: 10.1161/STROKEAHA.110.598540.
  17. Harrison JK, McArthur KS, Quinn TJ. Assessment scales in stroke: clinimetric and clinical considerations. Clin Interv Aging. 2013; 8: 201–11. DOI: 10.2147/CIA.S32405.
  18. Adams HP, Bendixen BH, Kappelle LJ, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 1993; 24: 35–41. DOI: 10.1161/01.STR.24.1.35.
  19. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2013; 36: S67–S74. PMID:15618111.
  20. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001; 414 (6865): 813–20. DOI: 10.1038/414813a.
  21. Nishikawa T, Kukidome D, Sonoda K, Fujisawa K, Matsuhisa T, Motoshima H, et al. Impact of mitochondrial ROS production on diabetic vascular complications. Diabetes Res Clin Pract. 2007; 77 Suppl 1: S41–5. DOI: 10.1016/j.diabres.2007.01.031.
  22. Smith CJ, Lawrence CB, Rodriguez-Grande B, Kovacs KJ, Pradillo JM, Denes A. The immune system in stroke: clinical challenges and their translation to experimental research. J Neuroimmune Pharmacol. 2013; 8 (4): 867–87. DOI: 10.1007/ s11481-013-9469-1.
  23. Poulsen RC, Knowles HJ, Carr AJ, Hulley PA. Cell differentiation versus cell death: extracellular glucose is a key determinant of cell fate following oxidative stress exposure. Cell Death Dis. 2014; 5 (2): e1074. DOI: 10.1038/cddis.2014.52.
  24. Stratton IM, Adler AI, Neil HA, Matthews DR, Manley SE, Cull CA, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ. 2000; 321 (7258): 405–12. DOI: 10.1136/bmj.321.7258.405.
  25. Bruno A, Liebeskind D, Hao Q, Raychev R; UCLA Stroke Investigators. Diabetes mellitus, acute hyperglycemia, and ischemic stroke. Curr Treat Options Neurol. 2010; 12 (6): 492–503. DOI: 10.1007/s11940-010-0093-6.
  26. Venkat P, Chopp M, Chen J. Blood-Brain Barrier Disruption, Vascular Impairment, and Ischemia/Reperfusion Damage in Diabetic Stroke. J Am Heart Assoc. 2017; 6 (6): e005819. DOI: 10.1161/JAHA.117.005819.
  27. Jones DP. Redox potential of GSH/GSSG couple: assay and biological significance. Methods Enzymol. 2002; 348: 93–112. DOI: 10.1016/s0076-6879(02)48630-2.
  28. Wu G, Fang YZ, Yang S, Lupton JR, Turner ND. Glutathione metabolism and its implications for health. J Nutr. 2004; 134 (3): 489–92. DOI: 10.1093/jn/134.3.489.
  29. Etemad A, Vasudevan R, Aziz AF, Yusof AK, Khazaei S, Fawzi N, et al. Analysis of selected glutathione S-transferase gene polymorphisms in Malaysian type 2 diabetes mellitus patients with and without cardiovascular disease. Genet Mol Res. 2016; 15 (2). DOI: 10.4238/gmr.15025845.