ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Gut microbiota alterations and their relationship to the disease severity and some cytokine profile indicators in patients with COVID-19
About authors
V.I. Vernadsky Crimean Federal University, Simferopol, Russia
Correspondence should be addressed: Leya E. Sorokina
Bulvar Lenina, 5/7, Simferopol, 295006, Republic of Crimea; ur.liam@anikoros.ayel
About paper
Author contribution: Gumenyuk LN, Sorokina LE — significant contribution to the study concept and design; Golod MV, Silaeva NV, Androschyuk NA — data acquisition, analysis, and interpretation; Ilyasov SS — statistical data processing; Krivoshapko OR, Velilyaev AM, Asanova LN — manuscript writing.
Compliance with ethical standards: the study was approved by the Ethics Committee of the S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University (protocol № 11 dated November 23, 2021), planned and conducted in accordance with the Declaration of Helsinki. The informed consent was obtained from all study participants.
Received: 2022-01-18
Accepted: 2022-02-02
Published online: 2022-02-19
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Fig. 1. Comparative analysis of the gut microbiota phylogenetic composition in patients with COVID-19 and healthy volunteers. IG — index group, CG — control group
Fig. 2. Comparative analysis of the genus-level gut microbiota composition in patients with COVID-19 and healthy volunteers. IG — index group, CG — control group
Table 1. Characteristics of patients with COVID-19 and healthy volunteers
Table 2. Clinical characteristics of patients with COVID-19
Note: RR — respiratory rate, HR — heart rate, SBP — systolic blood pressure, SO2 — oxygen saturation, CT — computed tomography
Table 3. Comparative analysis of cytokine profile in patients with COVID-19 and healthy volunteers (m ± CD)
