ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Development of a recombinant oncolytic poliovirus type 3 strain with altered cell tropism
About authors
1 Engelhardt Institute of Molecular Biology, Moscow, Russia
2 Moscow Institute of Physics and Technology (MIPT), Moscow, Russia
3 Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Moscow, Russia
4 Pirogov Russian National Research Medical University, Moscow, Russia
Correspondence should be addressed: Anastasia V. Lipatova
Vavilova, 32/1, Moscow, 119991, Russia; moc.liamg@vnaavotapil
About paper
Funding: the project was supported by the Russian Science Foundation (agreement number 20-75-10157 of 14 August 2020 “Research on the possibilities of obtaining recombinant strains of oncolytic viruses with tumor-specific replication and immunomodulatory protein expression”).
Author contribution: Chumakov PM, Lipatova AV — study concept and planning, data analysis; Hamad A, Vorobyev PO, Soboleva AV, Mahmoud M, Vasilenko KV, and Lipatova AV — laboratory experimental work; Hamad A, Soboleva AV, and Lipatova AV — preparation of figures and data interpretation.
Compliance with ethical standards: the study was conducted per the requirements of the World Medical Association Declaration of Helsinki 2000 and its subsequent revisions; in compliance with the principles of the European Convention for the Protection of Vertebrate Animals used for Experimental and other Scientific Purposes.
Received: 2022-04-18
Accepted: 2022-04-28
Published online: 2022-04-30
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