ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Regenerative effects of Gly-His-Lys and Gly-His-Lys-D-Ala peptides in infected skin wounds
About authors
Kursk State Medical University, Kursk, Russia
Correspondence should be addressed: Igor I. Bobyntsev
Karla Marxa, 3, Kursk, 305041, Russia; ur.liam@gibob
About paper
Author contribution: Rakhmetova KK — sample collection, concept and design of the study, data analysis and interpretation, writing of the manuscript; Mishina ES — histological and morphological examination, data analysis and interpretation; Vorvul AO — statistical processing of the data, writing of the manuscript; Bobyntsev II — concept and design of the study, scientific editing of the manuscript; Dolgintsev ME — data analysis and interpretation, writing of the manuscript; Bezhin AI — concept and design of the study.
Compliance with ethical standards: the study was approved by Ethics Committee of the Kursk State Medical University (Protocol № 1 of January 16, 2014). The study was carried out in compliance with the European Convention for the Protection of Vertebrate Animals used for Experimental and other Scientific Purposes and the Guidelines for conducting preclinical drug trials (Moscow, 2012).
Received: 2022-02-10
Accepted: 2022-03-01
Published online: 2022-04-13
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Fig. 1. Microphotographs of the skin wound area on day 10 post-wounding (H & E, magnification × 40). A. Control. B. GHK peptide, 0.5 µg/kg daily. C. GHK-D-Ala peptide, 0.5 µg/kg daily. D. GHK peptide, 1.5 µg/kg daily. E. GHK-D-Ala peptide, 1.5 µg/kg daily
Table. Dynamics of morphometric indicators upon injections of Gly-His-Lys-D-Ala peptide (M ± SD / Me [1Q; 3Q], n = 10) assessed by histological examination on days 3, 7, and 10 post-wounding
Note: * — p < 0.05; ** — p < 0.01; *** — p < 0.001 compared with the control group; # — p < 0.05; ## — p < 0.01; ### — p < 0.001 compared with the GHK 0.5 µg/kg group; $ — p < 0.05; $$ — p < 0.01; $$$ — p < 0.001 compared with the GHK 1.5 µg/kg group
