2022 / 02

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DOI: 10.24075/brsmu.2022.016

ORIGINAL RESEARCH

Effects of COVID-19 vector vaccine on autoantibody profile in reproductive age women

Dovgan AA, Drapkina YuS, Dolgushina NV, Menzhinskaya IV, Krechetova LV, Sukhikh GT
About authors

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia

Correspondence should be addressed: Alina А. Dovgan
Oparina, 4, Moscow, 117198, Russia; moc.liamg@nagvod.anil

About paper

Funding: the study was supported by the “Investment to the Future” Sberbank Charitable Foundation within the framework of “Stop the Coronavirus Together” initiative.

Author contributions: Dovgan AA, Drapkina YuS — patient management, manuscript writing; Dolgushina NV — literature research, manuscript editing, statistical analysis; Menzhinskaya IV, Krechetova LV — laboratory research, manuscript editing; Sukhikh GT — conclusive editing and approval of the manuscript.

Compliance with ethical standards: the study was approved by Ethical Review Board at Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology (Protocol No. 12 of November 26, 2020). All participants provided informed consent for the study.

Received: 2022-03-30 Accepted: 2022-04-14 Published online: 2022-04-21
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Fig. 1. Correlation analysis for possible dynamic associations between serum levels of hormones (ΔFSH, ΔAMH) and antiphospholipid antibodies (ΔaPL) in women before and after vaccination
Fig. 2. Correlation analysis for possible dynamic associations between serum levels of hormones (ΔFSH, ΔAMH) and autoantibodies (ΔautoAB) in women before and after vaccination
Table 1. Serum levels of antiphospholipid antibodies (aPL) in women before and after vaccination
Note: Mе (X–Y), p-values by the sign test.
Table 2. Prevalence of elevated serum aPL in women before and after vaccination
Note: p-values by McNemar’s test, RR — reference range.
Table 3. Serum levels of autoantibodies in women before and after vaccination
Note: Mе (X–Y), p-values by the sign test.
Table 4. Prevalence of elevated serum autoantibodies in women before and after vaccination
Note: p-values by McNemar’s test, RR — reference range.