2022 / 02

Next Paper
DOI: 10.24075/brsmu.2022.016

ORIGINAL RESEARCH

Effects of COVID-19 vector vaccine on autoantibody profile in reproductive age women

Dovgan AA, Drapkina YuS, Dolgushina NV, Menzhinskaya IV, Krechetova LV, Sukhikh GT
About authors

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia

Correspondence should be addressed: Alina А. Dovgan
Oparina, 4, Moscow, 117198, Russia; moc.liamg@nagvod.anil

About paper

Funding: the study was supported by the “Investment to the Future” Sberbank Charitable Foundation within the framework of “Stop the Coronavirus Together” initiative.

Author contributions: Dovgan AA, Drapkina YuS — patient management, manuscript writing; Dolgushina NV — literature research, manuscript editing, statistical analysis; Menzhinskaya IV, Krechetova LV — laboratory research, manuscript editing; Sukhikh GT — conclusive editing and approval of the manuscript.

Compliance with ethical standards: the study was approved by Ethical Review Board at Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology (Protocol No. 12 of November 26, 2020). All participants provided informed consent for the study.

Received: 2022-03-30 Accepted: 2022-04-14 Published online: 2022-04-21
|
  1. Enjuanes L, Zuñiga S, Castaño-Rodriguez C, Gutierrez-Alvarez J, Canton J, Sola I. Molecular Basis of Coronavirus Virulence and Vaccine Development. Adv Virus res. 2016; 96: 245–86.
  2. Logunov DY, Dolzhikova IV, Shcheblyakov DV, Tukhvatulin AI, Zubkova OV, Dzharullaeva AS, et al. Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia. Lancet. 2021; 397 (10275): 671–81.
  3. Orvieto R, Noach-Hirsh M, Segev-Zahav A, Haas J, Nahum R, Aizer A. Does mRNA SARS-CoV-2 vaccine influence patients’ performance during IVF-ET cycle? Reprod Biol Endocrinol. 2021; 19 (1): 69.
  4. Bentov Y, Beharier O, Moav-Zafrir A, Kabessa M, Godin M., Greenfield CS, et al. Ovarian follicular function is not altered by SARS–CoV-2 infection or BNT162b2 mRNA COVID-19 vaccination. Hum Reprod. 2021; 36 (9): 2506–13.
  5. Drapkina YS, Dolgushina NV, Shatylko TV, Nikolaeva MA, Menzhinskaya IV, Ivanets TY, et al. Gam-COVID-Vac (Sputnik V) vaccine has no adverse effect on spermatogenesis in men. Akusherstvo i Ginekol. 2021; 7: 88–94.
  6. Dolgushina NV, Drapkina YS, Krechetova LV, Ivanets TY, Menzhinskaya IV, Gus GAI, et al. Gam- COVID- Vac (Sputnik V) vaccine has no adverse effect on ovarian reserve in reproductive- age women. Akusherstvo i Ginekol. 2021; 7: 81–6.
  7. Gonzalez DC, Nassau DE, Khodamoradi K, Ibrahim E, BlachmanBraun R, Ory J, et al. Sperm Parameters Before and After COVID-19 mRNA Vaccination. JAMA. 2021; 326 (3): 273–4.
  8. World Health Organization (WHO). Module 2: types of vaccine and adverse reactions. WHO Vaccine Saf Basics. 2013: 38–60.
  9. Pellegrino P, Clementi E, Radice S. On vaccine’s adjuvants and autoimmunity: Current evidence and future perspectives. Autoimmun Rev. 2015; 14 (10): 880–8.
  10. Guimarães LE, Baker B, Perricone C, Shoenfeld Y. Vaccines, adjuvants and autoimmunity. Pharmacol Res. 2015; 100 (January): 190–209.
  11. Watad A, Bragazzi NL, McGonagle D, Adawi M, Bridgewood C, Damiani G, et al. Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype: Insights from an analysis of 500 cases. Clin Immunol. 2019; 203 (March): 1–8.
  12. Wang B, Shao X, Wang D, Xu D, Zhang J. Vaccinations and risk of systemic lupus erythematosus and rheumatoid arthritis: A systematic review and meta-analysis. Autoimmun Rev. 2017; 16 (7): 756–65.
  13. Cruz-Tapias P, Blank M, Anaya JM, Shoenfeld Y. Infections and vaccines in the etiology of antiphospholipid syndrome. Curr Opin Rheumatol. 2012; 24 (4): 389–93.
  14. Pis'mo Ministerstva zdravooxraneniya RF ot 30 oktyabrya 2021 g. N 30-4/I/2-17927 O napravlenii aktualizirovannyx vremennyx metodicheskix rekomendacij «Poryadok provedeniya vakcinacii vzroslogo naseleniya protiv COVID-19». Available from: https:// base.garant.ru/403013668/#block_. Russian.
  15. Shoenfeld Y, Agmon-Levin N. “ASIA” — autoimmune/inflammatory syndrome induced by adjuvants. J Autoimmun. 2011; 36 (1): 4–8.
  16. Kraevaya ЕЕ, Dolgushina NV, Menzhinskaya IV, Shpilyuk МА, Beznoshchenko ОS, Krechetova LV. Outcomes of assisted reproductive technologies in patients with persistence оf antiphospholipid antibodies. Akush Ginekol (Sofiia). 2020; 4: 97–103.
  17. Shoenfeld Y, Carp HJA, Molina V, Blank M, Cervera R, Balasch J, et al. Autoantibodies and Prediction of Reproductive Failure. Am J Reprod Immunol. 2006; 56 (5–6): 337–44.
  18. Aleksandrova EN, Novikov AA, Nasonov EL. Sovremennye podxody k laboratornoj diagnostike revmaticheskix zabolevanij: rol' molekulyarnyx i kletochnyx biomarkerov. Nauchnoprakticheskaya revmatologiya. 2016; 3: 324–38. Russian.
  19. Pisetsky DS. Antinuclear Antibodies in Rheumatic Disease: A Proposal for a Function-Based Classification. Scand J Immunol. 2012; 76 (3): 223–8.
  20. Alves MR, Isenberg DA. “Mixed connective tissue disease”: a condition in search of an identity. Clin Exp Med. 2020; 20 (2): 159–66.
  21. Pires ES, Parikh FR, Mande PV, Uttamchandani SA, Savkar S, Khole VV. Can anti-ovarian antibody testing be useful in an IVF-ET clinic? J Assist Reprod Genet. 2011; 28 (1): 55–64.
  22. Trimboli P, Rossi F, Condorelli E, Laurenti O, Ventura C, Nigri G, et al. Does Normal Thyroid Gland by Ultrasonography match with Normal Serum Thyroid Hormones and Negative Thyroid Antibodies? Exp Clin Endocrinol Diabetes. 2009; 118 (09): 630–2.
  23. Bessis S, Bertin D, Million M, Meddeb L, Drancourt M, Lagier J-C, et al. Thromboses in tuberculosis are linked to antiphosphatidylethanolamine antibodies levels: A cross-sectional study. J Clin Tuberc Other Mycobact Dis. 2019; 15: 100092.
  24. Goodridge A, Zhang T, Miyata T, Lu S, Riley LW. Antiphospholipid IgM antibody response in acute and chronic Mycobacterium tuberculosis mouse infection model. Clin Respir J. 2014; 8 (2): 137–44.
  25. Grayzel A, Solomon A, Aranow C, Diamond B. Antibodies elicited by pneumococcal antigens bear an anti-DNA--associated idiotype. J Clin Invest. 1991; 87 (3): 842–6.
  26. Fournié GJ, Lambert PH, Miescher PA. Release of DNA in circulating blood and induction of anti-DNA antibodies after injection of bacterial lipopolisaccharides. J Exp Med. 1974; 140 (5): 1189–206.
  27. Toplak N, Avčin T. Autoantibodies Induced by Vaccine. In: Vaccines and Autoimmunity. Hoboken, NJ, USA: John Wiley & Sons, Inc, 2015; p. 93–102.
  28. Ding T, Wang T, Zhang J, Cui P, Chen Z, Zhou S, et al. Analysis of Ovarian Injury Associated With COVID-19 Disease in Reproductive-Aged Women in Wuhan, China: An Observational Study. Front Med. 2021; 8.
  29. Dolgushin GO, Romanov AY. Effects of SARS-CoV-2 on human reproduction. Akush Ginekol (Sofiia). 2020; 11: 6–12.