2022 / 04

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DOI: 10.24075/brsmu.2022.041

ORIGINAL RESEARCH

Androgen levels in blood and follicular fluid of IVF patients with diminished ovarian reserve

Gavisova AA, Shevtsova MA, Kindysheva SV, Starodubtseva NL, Frankevich VE, Nazarenko TA, Dolgushina NV
About authors

Kulakov national medical research center for obstetrics, gynecology and perinatology, Moscow, Russia

Correspondence should be addressed: Alla A. Gavisova
Akademika Oparina, 4, Moscow, 117997; ur.ay@allaivag

About paper

Author contribution: Gavisova AA, Dolgushina NV — stady concept and design; Gavisova AA, Shevtsova MA — analysis, manuscript writing; Kindysheva SV — laboratory tests, statistial analysis; Starodubtseva NL, Nazarenko TA, Frankevich VE, Dolgushina NV — manuscript editing.

Compliance with ethical standards: the study was approved by the ethical review board at the Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology (protocol № 140 of 15 December 2014). The informed consent was submitted by all study participants.

Received: 2022-07-29 Accepted: 2022-08-13 Published online: 2022-08-19
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Fig. 1. Block-scheme of the study
Fig. 2. Correlation coefficients for hormone concentrations in plasma vs follicular fluid as measured by LC-MS/MS in patients with infertility and diminished ovarian reserve
Fig. 3. The concentrations of androstenedione in follicular fluid (FF) and blood plasma per groups: younger than 35 years (group 1), aged 35–38 years (group 2a) and older than 39 years (group 2b), with ovarian reserves diminished (subgroup 1) or normal (subgroup 0)
Fig. 4. The DHEA-S levels in follicular fluid (FF) and blood plasma per groups: younger than 35 years (group 1), aged 35–38 years (group 2a) and older than 39 years (group 2b), with poor ovarian reserves (subgroup 1) or normal (subgroup 0)
Fig. 5. The correlation and linear regression analyses of DHEA-S concentrations in follicular fluid (FF) vs blood plasma for all data points