ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
Copyright: © 2022 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
ORIGINAL RESEARCH
The role of mef and ermB drug resistance genetic markers in the selection of fecal microbiota donors
About authors
1 Lopukhin Federal Research and Clinical Center Of Physical-Chemical Medicine under the Federal Medical Biological Agency, Moscow, Russia
2 Mendeleev University of Chemical Technology of Russia, Moscow, Russia
3 Semashko National Research Institute of Public Health, Moscow, Russia
Correspondence should be addressed: Alina V. Gospodaryk
Krasnogorskoe shosse, 15, Odintsovo, Moscow region, 143007, Russia; gro.mcpcr@kiradopsog.anila
About paper
Funding: Grant of ANO Moscow Center for Innovative Technologies in Healthcare (#2412-31).
Author contribution: Gospodaryk AV — selection of study participants, PCR analysis of biological samples, literature analysis, article authoring; Ulakhanova LA — literature analysis, article authoring, fecal culture, bacteriological analysis; Esiev SS — literature analysis, isolation of nucleic acids from biological samples; Polyakova EV — practical part of the bacteriological analysis, isolation of nucleic acids from biological samples; Shansky YD — statistical data processing; Bespyatykh JA — study concept, consulting, article authoring and editing.
Compliance with ethical standards: the study was approved by the Ethics Committee of the Federal Research and Clinical Center Of Physical-Chemical Medicine under the Federal Medical Biological Agency of Russia (Minutes #2022/05/31 of May 31, 2022). All study participants signed the voluntary informed consent form.
Received: 2022-10-20
Accepted: 2022-11-25
Published online: 2022-12-16
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Table 1. Stool culture method
Table 2. Bacteria culture test, stool samples from potentially healthy volunteers
Table 3. Prevalence of mef and ermB resistance genes in feces, different age groups
Note: * — ratio of the number of samples in which the gene was detected to the total number of samples in the respective group.
Table 4. Prevalence of mefA and ermB resistance genes in the "mother-child" group
Note: * — ratio of the number of samples in which the gene was detected to the total number of samples in the respective group.
