ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Biochemical and morphological substantiation of the connective tissue hypothesis of mandibular third molar eruption
About authors
1 Omsk State Medical University, Omsk, Russia
2 Central Research Institute of Dentistry and Maxillofacial Surgery, Moscow, Russia
3 Omsk State Pedagogical University, Omsk, Russia
4 City Clinical Dental Polyclinic № 1, Omsk, Russia
Correspondence should be addressed: Andrey S. Korshunov
Kosareva, 34, Omsk, 644043, Russia; ur.liam@885081_k_yerdna
About paper
Author contribution: Korshunov AS — study planning, literature analysis, data interpretation, clinical data acquisition, manuscript writing; Vagner VD — study planning, literature analysis, data interpretation; Belskaya LV — study planning, biochemical investigations, manuscript writing; Kuryatnikov KN — clinical data acquisition, literature analysis, data interpretation, manuscript writing; Serov DO — clinical data acquisition, data interpretation, literature analysis; Krasnov VA — clinical data acquisition, sample preparation for assessment; Tigranyan GO, Bondar IA — sample preparation for assessment, data analysis.
Compliance with ethical standards: the study was approved by the Ethics Committee of the Omsk State Medical University (extract from the protocol № 113 of 26 November 2019); the informed consent was submitted by all study participants or their legal representatives.
Received: 2023-07-31
Accepted: 2023-08-23
Published online: 2023-08-31
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Fig. 1. Structure of dentinal tubules, packaging of enamel prisms in the surface and deep layers (scanning electron microscopy; 1500× magnification). Structure of dentinal tubules: 14–17 years (А); 18–21 years (B); 22–26 years (C); 27–31 years (D); 32–36 years (E). Packaging of enamel prisms in the surface layer: 14–17 years (F); 18–21 years (G); 22–26 years (H); 27–31 years (I); 32–36 years (J). Packaging of enamel prisms in the deep layer: 14–17 years (K); 18–21 years (L); 22–26 years (M); 27–31 years (N); 32–36 years (O)
Fig. 2. Relative changes in the intensities of the IR spectra absorption bands: Enamel (А), dentin–enamel junction (B), dentin in various age groups relative to the group aged 14–17 (%) (C)
Fig. 3. Principal component analysis of IR spectra of various age groups: enamel (А), dentin (B); dentin–enamel junction: individual factor chart (C), variable factor map (D)
Table 1. Size of the dentin layer and dentinal tubules of mandibular third molars of the surveyed patients during various eruption phases
Note: * — differences between tooth eruption phases; * * — significant differences between age groups (Mann–Whitney U test, Wilcoxon signed-rank test, Bonferroni corrected at p < 0.02). No significant differences in/between age groups have been revealed (p > 0.05). 1 — tooth germ phase; 2 — tooth grown to the level of the gum; 3 — tooth grown to the mid-crown of the second molar; 4 — fully erupted tooth.
Table 2. Width of enamel prisms in various enamel layers of mandibular third molars of the surveyed patients during various eruption phases
Note: * — differences between tooth eruption phases; * * — significant differences between age groups (Mann–Whitney U test, Wilcoxon signed-rank test, Bonferroni corrected at p < 0.02). No significant differences in/between age groups have been revealed (p > 0.05). 1 — tooth germ phase; 2 — tooth grown to the level of the gum; 3 — tooth grown to the mid-crown of the second molar; 4 — fully erupted tooth.
Table 3. Water content of the mandibular third molar hard tissues during various eruption phases in the group of surveyed patients
Note: * — differences between tooth eruption phases; * * — significant differences between age groups (Mann–Whitney U test, Wilcoxon signed-rank test, Bonferroni corrected at p < 0.02). No significant differences between age groups have been revealed (p > 0.05). 1 — tooth germ phase; 2 — tooth grown to the level of the gum; 3 — tooth grown to the mid-crown of the second molar; 4 — fully erupted tooth.
