2023 / 06

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DOI: 10.24075/brsmu.2023.047

ORIGINAL RESEARCH

Comparative bioinformatics analysis of antimicrobial resistance gene pool in the genomes of representatives of genus Corynebacterium

Kulshan TA, Bugaeva IO, Soboleva EF, Allyanova MS, Popov DA, Shvidenko IG
About authors

Razumovsky Saratov State Medical University, Saratov, Russia

Correspondence should be addressed: Tatiana А. Kulshan
B. Kazachiya, 112, Saratov, 410012, Russia; ur.xednay@nahsluk.anajtat

About paper

Author contribution: Kulshan TА — study planning, literature review, dealing with molecular genetic data (selection of genomes, genome annotation, comparative analysis of gyrA amino acid sequences), data analysis, manuscript writing; Bugaeva IO — study planning, data analysis, interpretation of findings, manuscript writing; Soboleva EF — literature review, data analysis, manuscript writing; Allyanova MS — literature review, analysis of the antimicrobial resistance gene pool in the genomes of corynebacterial strains, dealing with the PATRIC online service; Popov DA — literature review, search for gyrA amino acid sequences in the genomes of corynebacterial strains, comparative analysis of amino acid sequences; Shvidenko IG — advising during manuscript writing, data analysis.

Received: 2023-10-20 Accepted: 2023-12-03 Published online: 2023-12-19
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Fig. The gyrA amino acid sequence of Corynebacterium non diphtheriae isolates taken as examples. Positions of point mutations found in the gyrA amino acid sequence, which, according to the literature, affect the increase in the quinolone/fluoroquinolone minimum inhibitory concentrations (MICs), are marked with frames
Table 1. Corynebacterium non diphtheriae strains, the whole genome nucleotide sequences of which are used in the study
Table 2. List of antimicrobial resistance genes found in the genomes of the studied Corynebacterium non diphtheriae strains using the PATRIC online resource
Table 3. List of antimicrobial resistance genes not found found in the genomes of the studied Corynebacterium non diphtheriae strains