ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ
Особенности микробиоты кишечника у женщин с идиопатическим привычным выкидышем
Медицинский институт имени С. И. Георгиевского (структурное подразделение Крымского федерального университета имени В. И. Вернадского), Симферополь, Россия
Для корреспонденции: Леся Николаевна Гуменюк
бул. Ленина, 5/7, 295006, г. Симферополь, Республика Крым; ur.liam@kuynemyg_aysel
Вклад авторов: Л. Н. Гуменюк — идея и дизайн исследования; М. Д. Бордюгов, Е. В. Сарчук — сбор, анализ и интерпретация данных; С. В. Князева, В. А. Заставский — статистическая обработка данных; Д. В. Крицкая, Ш. Э. Сайтибрагимова, А. И. Куртвелиева — написание статьи.
Соблюдение этических стандартов: исследование одобрено этическим комитетом Медицинского института имени С. И. Георгиевского ФГАОУ ВО «Крымский федеральный университет имени В. И. Вернадского» (протокол № 10 от 16 октября 2021 г.), спланировано и проведено в соответствии с Хельсинской декларацией. Все лица, включенные в исследование, подписали добровольное информированное согласие.
- Practice Committee of American Society for Reproductive Medicine. Definitions of infertility and recurrent pregnancy loss: a committee opinion. Fertil Steril. 2013; 99 (1): 63.
- El Hachem H, Crepaux V, May-Panloup P, et al. Recurrent pregnancy loss: current perspectives. Int J Women's Health. 2017; 9: 31–45.
- Lund M, Kamper-Jørgensen M, Nielsen HS, et al. Prognosis for live birth in women with recurrent miscarriage: what is the best measure of success? Obstet Gynecol. 2012; 119 (1): 37–43.
- Jeve YB, Davies W. Evidence-based management of recurrent miscarriages. J Hum Reprod Sci. 2014; 7: 159–69.
- Abu-Heija A. Thrombophilia and Recurrent Pregnancy Loss: Is heparin still the drug of choice? Sultan Qaboos Univ Med J. 2014; 14 (1): e26–36.
- Zejnullahu VA, Zejnullahu VA, Kosumi E. The role of oxidative stress in patients with recurrent pregnancy loss: a review. Reprod Health. 2021; 16; 18 (1): 207.
- Kniotek M, Zych M, Roszczyk A, et al. Decreased Production of TNFα and IL6 Inflammatory Cytokines in Non-Pregnant Idiopathic RPL Women Immunomodulatory Effect of Sildenafil Citrate on the Cellular Response of Idiopathic RPL Women. J Clin Med. 2021; 15; 10 (14): 3115.
- Mor G, Aldo P, Alvero AB. The unique immunological and microbial aspects of pregnancy. Nat Rev Immunol. 2017; 17 (8): 469–82.
- Yang X, Tian Y, Zheng L, et al. The Update Immune-Regulatory Role of Pro- and Anti-Inflammatory Cytokines in Recurrent Pregnancy Losses. Int J Mol Sci. 2023; 21; 24 (1): 132.
- Dai FF, Hu M, Zhang YW, et al. TNFα/anti-TNFαdrugs and its effect on pregnancy outcomes. Expert Rev Mol Med. 2022; 10: 24–26.
- Saifi B, Rezaee SA, Tajik N, et al. Th17 cells and related cytokines in unexplained recurrent spontaneous miscarriage at the implantation window. Reprod Biomed Online. 2014; 29: 481–9.
- Piccinni MP, Raghupathy R, Saito S, Szekeres-Bartho J. Cytokines, Hormones and Cellular Regulatory Mechanisms Favoring Successful Reproduction. Front Immunol. 2021; 28; 12: 717808.
- Shaarawy M, Nagui AR. Enhanced expression of cytokines may play a fundamental role in the mechanisms of immunologically mediated recurrent spontaneous abortion. Acta Obstet Gynecol Scand. 1997; 76: 205–11.
- Kilani RT, Mackova M, Davidge ST et al. Endogenous tumor necrosis factor — mediates enhanced apoptosis of cultured villous trophoblasts from intrauterine growth-restricted placentae. Reproduction. 2007; 133: 257–64.
- Salama KM, Alloush MK,Hussini RM. Are the cytokines TNF alpha and IL 1Beta early predictors of embryo implantation? Cross sectional study. J Reprod Immunol. 2020; 137: 102618.
- Azizieh FY, Raghupathy RG. Tumor necrosis factor-α and pregnancy complications: a prospective study. Med Princ Pract. 2015; 24 (2): 165–70.
- Zhang Y, Zhang Y, Li H, et al. NOD1 modulates decidual stromal cell function to maintain pregnancy in the early trimester. Cell Biochemistry and Function 2019; 37: 464–73.
- Yang SL, Tan HX, Niu TT, et al. Kynurenine promotes the cytotoxicity of NK cells through aryl hydrocarbon receptor in early pregnancy. J Reprod Immunol. 2021; 143: 103270.
- Najafi S, Hadinedoushan H, Eslami G, Aflatoonian A. Association of IL17A and IL17 F gene polymorphisms with recurrent pregnancy loss in Iranian women. J Assist Reprod Genet. 2014; 31 (11): 1491–6.
- Buzzaccarini G, Vitagliano A, Andrisani A, et al. Chronic Endometritis and Altered Embryo Implantation: A Unified Pathophysiological Theory from a Literature Systematic Review. J Assist Reprod Genet. 2020; 37: 2897–2911.
- Lee SK, Kim JY, Lee M, et al. Th17 and regulatory T cells in women with recurrent pregnancy loss. Am J Reprod Immunol. 2012; 67: 311–8.
- Sha J, Liu F, Zhai J, et al. Alteration of Th17 and Foxp3+regulatory T cells in patients with unexplained recurrent spontaneous abortion before and after the therapy of hCG combined with immunoglobulin. Exp Ther Med. 2017; 14: 1114–8.
- McCarthy R, Jungheim ES, Fay JC, et al. Riding the rhythm of melatonin through pregnancy to deliver on time. Front Endocrinol (Lausanne). 2019; 13 (10): 616.
- Nepomnaschy PA, Welch KB, McConnell DS. et al. Cortisol levels and very early pregnancy loss in humans. Proc Natl Acad Sci USA. 2006; 103: 3938–42.
- Palmer KT, Bonzini M, Harris EC, et al. Europe PMC Funders Group Work activities and risk of prematurity, low birthweight and preeclampsia: an updated review with meta-analysis. Occup Environ Med. 2013; 70: 213–22.
- Kisanga EP, Tang Z, Guller S, Whirledge S. Glucocorticoid signaling regulates cell invasion and migration in the human firsttrimester trophoblast cell line Sw.71. Am J Reprod Immunol. 2018; 80: e12974.
- Húngaro TGR, Gregnani MF, Alves-Silva T, et al. Cortisol dosedependently impairs migration and tube-like formation in a trophoblast cell line and modulates inflammatory and angiogenic genes. Biomedicines. 2021; 9 (8): 980.
- Michael AE, Papageorghiou AT. Potential significance of physiological and pharmacological glucocorticoids in early pregnancy. Hum Reprod Update. 2008; 14 (5): 497–517.
- Magiakou MA, Mastorakos G, Webster E. The Hypothalamicpituitary-adrenal axis and the female reproductive system, annals of the new. 1997; 17 (816): 42–56.
- Sandyk R, Anastasiadis PG, Anninos PA, Tsagas N. The pineal gland and spontaneous abortions: Implications for therapy with melatonin and magnetic field. Int J Neurosci.1992; 62 (3–4): 243–50.
- Jin M, Li D, Ji R, et al. Changes in Gut Microorganism in Patients with Positive Immune Antibody-Associated Recurrent Abortion. Biomed Res Int. 2020; 18: 4673250.
- Cui Y, Zou L, Ye Q, et al. Gut microbiota composition and functional prediction in recurrent spontaneous abortion. Research Square; 2021.
- Liu Y, Chen H, Feng L, Zhang J. Interactions between gut microbiota and metabolites modulate cytokine network imbalances in women with unexplained miscarriage. NPJ Biofilms Microbiomes. 2021; 17; 7 (1): 24.
- ESHRE Guideline Group on RPL. Bender Atik R, Christiansen OB, Elson J, et al. ESHRE guideline: recurrent pregnancy loss: an update in 2022. Hum Reprod Open. 2023; 2023 (1): hoad002.
- Mitra S, Forster-Fromme K, Damms-Machado A, et al. Analysis of the intestinal microbiota using SOLiD16S rRNA gene sequencing and SOLiD shotgun sequencing. BMC Genomics. 2013; 14 (5): 16.
- Caporaso JG, Kuczynski J, Stombaugh J, et al. QIIME allows analysis of high-throughput community sequencing data. Nat Methods. 2010; 7 (5): 335–6.
- DeSantis TZ, Hugenholtz P, Larsen N. Greengenes, a chimerachecked 16S rRNA gene database and workbench compatible with ARB. Appl Environ Microbiol. 2006; 72: 5069–72.
- Ritari J, Salojärvi J, Lahti L, de Vos WM. Improved taxonomic assignment of human intestinal 16S rRNA sequences by a dedicated reference database. BMC Genomics. 2015; 16 (1): 1056.
- Guang Y, Shen X, Tan Y, et al. Systematic analysis of microbiota in pregnant Chinese women and its association with miscarriage. Ann Transl Med. 2022; 10 (20): 1099.
- Vinolo MAR, Rodrigues HG, Nachbar RT, Curi R. Regulation of Inflammation by Short Chain Fatty Acids. Nutrients. 2011; 3 (10): 858–76.
- Zhang Q, Hu WM, Deng YL, et al. Dysbiosis of gut microbiota and decreased propionic acid associated with metabolic abnormality in Cushing's syndrome. Front Endocrinol (Lausanne). 2023; 13: 1095438.
- Michels N, Van de Wiele T, Fouhy F, et al. Gut microbiome patterns depending on children's psychosocial stress: Reports versus biomarkers. Brain Behav Immun. 2019; 80: 751–62.
- Ziegler DR, Herman JP. Neurocircuitry of stress integration: anatomical pathways regulating the hypothalamopituitaryadrenocortical axis of the rat1. Integr Comp Biol. 2002; 42: 541–51.
- Van de Wouw M, Boehme M, Lyte JM, et al. Short-chain fatty acids: microbial metabolites that alleviate stress-induced brain– gut axis alterations. J Appl Physiol. 2018; 596: 4923–44.
- Dalile B, Vervliet B, Bergonzelli G, et al. Colon-delivered shortchain fatty acids attenuate the cortisol response to psychosocial stress in healthy men: a randomized, placebo-controlledtrial. Neuropsychopharmacol. 2020; 45: 2257–66.
- Song L, He M, Sun Q, et al. Roseburia hominis Increases Intestinal Melatonin Level by Activating p-CREB-AANAT Pathway. Nutrients. 2022; 14: 117.
- Поросюк М. В., Клементьев Д. Д., Ходов Н. А., и др. Изменения микробиоты кишечника у больных ювенильным идиопатическим артритом. Вестник РГМУ. 2022; (6): 13–9.
- Huang X, Qiu Y, Gao Y, et al. Gut microbiota mediate melatonin signalling in association with type 2 diabetes. Diabetologia. 2022; 65 (10): 1627–41.
- Henke MT, Kenny DJ, Cassilly CD, et al. Ruminococcus gnavus, a member of the human gut microbiome associated with Crohn’s disease, produces an inflammatory polysaccharide. Proc Natl Acad Sci. 2019; 116: 12672–7.
- Bromberg JS, Hittle L, Xiong Y, et al. Gut microbiota-dependent modulation of innate immunity and lymph node remodeling affects cardiac allograft outcomes. JCI Insight [Internet]. 2018; 3 (19): e121045.
- Miao T, Yu Y, Sun J, et al. Decrease in abundance of bacteria of the genus Bifidobacterium in gut microbiota may be related to pre-eclampsia progression in women from East China. Food Nutr Res. 2021; 28; 65.
- Vatanen T, Kostic AD, d'Hennezel E, et al. DIABIMMUNE Study Group Variation in microbiome LPS immunogenicity contributes to autoimmunity in humans Cell. 2016; 165: 842–53.
- Henrick BM, Chew S, Casaburi G, et al. Colonization by B. infantis EVC001 modulates enteric inflammation in exclusively breastfed infants Pediatr. Res. 2019; 86: 749–57.
- Feng Y, Duan Y, Xu Z, et al. An examination of data from the American Gut Project reveals that the dominance of the genus Bifidobacterium is associated with the diversity and robustness of the gut microbiota. Microbiologyopen. 2019; 8 (12): e939.