2024 / 02

DOI: 10.24075/brsmu.2024.016

ORIGINAL RESEARCH

Amino acid profile in diminished ovarian reserve

Gavisova AA1, Shevtsova MA1, Lvova PO1, Biryukova DA1, Ibragimova MH1, Novoselova AV1, Yushina MN1, Chagovets VV1, Frankevich VE1,2
About authors

1 Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia

2 Siberian State Medical University, Tomsk, Russia

Correspondence should be addressed: Alla A. Gavisova
Akademika Oparina, 4, Moscow, 117997, Russia; ur.ay@allaivag

About paper

Author contribution: Gavisova AA — study design, data acquisition and processing, manuscript writing, editing; Shevtsova MA, Biryukova DA, Lvova PO — study design, data acquisition and processing, literature review, manuscript writing, editing; Novoselova AV, Yushina MN — developing the LC-MS method for analysis of amino acids in blood plasma and follicular fluid, experimental data processing; Ibragimova MH — data acquisition, editing; Chagovets VV, Frankevich VE — statistical data processing, editing.

Compliance with ethical standards: the study was approved by the Ethics Committee of the Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology (protocol № 12 dated 25 November 2021).

Received: 2024-03-27 Accepted: 2024-04-22 Published online: 2024-04-30
|
  1. Hu S. Perinatal outcome in young patients with diminished ovarian reserve undergoing assisted reproductive technology / S. Hu, B. Xu, L. Jin // Fertility and Sterility. 2020; 114 (1): 118–124.e1.
  2. Collado-Fernandez E, Picton HM, R. Dumollard ColladoFernandez E. Metabolism throughout follicle and oocyte development in mammals. The International Journal of Developmental Biology. 2012; 56 (10-11-12): 799–808.
  3. Dillin A, Gottschling DE, T. Nyström Dillin A. The good and the bad of being connected: the integrons of aging. Current Opinion in Cell Biology. 2014; 26: 107–12.
  4. Yang J, Feng T, Li S, et al. Human follicular fluid shows diverse metabolic profiles at different follicle developmental stages. Reproductive Biology and Endocrinology. 2020; 18 (1): 74.
  5. Moslehi N, Mirmiran P, Marzbani R. et al. Serum metabolomics study of women with different annual decline rates of antiMüllerian hormone: an untargeted gas chromatography–mass spectrometry-based study. Human Reproduction. 2021; 36 (3): 721–33.
  6. Shevtsova SMA, Gavisova GAA, Krasnova KNA, et al. Amino acid profile of blood plasma and follicular fluid in women with infertility and diminished ovarian reserve. Akusherstvo i ginekologiia. 2024; 2 (2024): 79–88.
  7. Klinicheskie rekomendacii "Zhenskoe besplodie". 2021.
  8. RStudio Team. RStudio: Integrated Development for R. RStudio, Inc., Boston, MA; 2016. Available from: http://www.rstudio.com/.
  9. Misra BB. Data normalization strategies in metabolomics: Current challenges, approaches, and tools. European Journal of Mass Spectrometry. 2020; 26 (3): 165–74.
  10. Zhang X, Yoshihara K, Miyata N, et al. Dietary tryptophan, tyrosine, and phenylalanine depletion induce reduced food intake and behavioral alterations in mice. Physiology & Behavior. 2022; 244: 113653.
  11. Deanfield JE, Halcox JP, Rabelink TJ. Endothelial Function and Dysfunction. Circulation. 2007; 115 (10): 1285–95.
  12. Li J, Zhang Z, Wei Y, et al. Metabonomic analysis of follicular fluid in patients with diminished ovarian reserve. Frontiers in Endocrinology. 2023; 14. DOI: 10.3389/fendo.2023.1132621.
  13. Ross AC, Caballero BH, Cousins RJ, et al. Modern nutrition in health and disease: Eleventh edition. Wolters Kluwer Health Adis (ESP). 2012; 1616 p.
  14. Rasmussen DD, Ishizuka B, Quigley ME, Yen SSC. Effects of tyrosine and tryptophan ingestion on plasma catecholamine and 3,4-dihydroxyphenylacetic acid concentrations. The Journal of Clinical Endocrinology & Metabolism. 1983; 57 (4): 760–3.
  15. van Overveld F. W. P. C., Haenen G. R. M. M., Rhemrev J, et al. Tyrosine as important contributor to the antioxidant capacity of seminal plasma. Chemico-Biological Interactions. 2000; 127 (2): 151–61.
  16. Dubé F, Amireault P. Local serotonergic signaling in mammalian follicles, oocytes and early embryos. Life Sciences. 2007; 81 (25–26): 1627–37.
  17. Liu A, Shen H, Li Q, et al. Determination of tryptophan and its indole metabolites in follicular fluid of women with diminished ovarian reserve. Scientific Reports. 2023; 13 (1): 17124.
  18. DuPont JJ, Farquhar WB, Townsend RR, Edwards DG. Ascorbic acid or l -arginine improves cutaneous microvascular function in chronic kidney disease. Journal of Applied Physiology. 2011; 111 (6): 1561–7.
  19. Takasaki A, Tamura H, Miwa I, et al. Endometrial growth and uterine blood flow: a pilot study for improving endometrial thickness in the patients with a thin endometrium. Fertility and Sterility. 2010; 93 (6): 1851–8.
  20. Luo Y, Zhu Y, Basang W, et al. Roles of nitric oxide in the regulation of reproduction: a review. Frontiers in Endocrinology. 2021; 12.
  21. Kopets R, Kuibida I, Chernyavska I, et al. Dietary supplementation with a novel l ‐carnitine multi‐micronutrient in idiopathic male subfertility involving oligo‐, astheno‐, teratozoospermia: a randomized clinical study. Andrology. 2020; 8 (5): 1184–93.
  22. D’Aniello G, Grieco N, Di Filippo MA, et al. Reproductive implication of D-aspartic acid in human pre-ovulatory follicular fluid. Human Reproduction. 2007; 22 (12): 3178–83.
  23. Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A-deficient mice. Rountree CB, Senadheera S, Mato JM, et al. Hepatology. 2007; 47 (4): 1288–97.
  24. Akamine K, Mekaru K, Gibo K, et al. Impact of the one‐carbon metabolism on oocyte maturation, fertilization, embryo quality, and subsequent pregnancy. Reproductive Medicine and Biology. 2021; 20 (1): 76–82.
  25. Tatone C, Amicarelli F. The aging ovary — the poor granulosa cells. Fertility and Sterility. 2013; 99 (1): 12–17.
  26. Chappel S. The role of mitochondria from mature oocyte to viable blastocyst. Obstetrics and Gynecology International. 2013; 2013: 1–10.
  27. Youssef M. A. F. M., Abdelmoty HI, Elashmwi HA, et al. Oral antioxidants supplementation for women with unexplained infertility undergoing ICSI/IVF: Randomized controlled trial. Human Fertility. 2015; 18 (1): 38–42.
  28. Anchordoquy JP, Lizarraga RM, Anchordoquy JM, et al. Effect of cysteine, glutamate and glycine supplementation to in vitro fertilization medium during bovine early embryo development. Reproductive Biology. 2019; 19 (4): 349–55.