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ORIGINAL RESEARCH
Assessment of the effect of hypothermia after simulated hypoxic ischemic encephalopathy based on blood metabolome
1 Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia
2 Belozersky Institute Of Physico-Chemical Biology, Moscow State University, Moscow, Russia
Correspondence should be addressed: Chupalav M. Eldarov
Akademika Oparina, 4, Moscow, 117997, Russia; ur.val4puhc@em
Funding: the study was supported by the Russian Federation on behalf of the Russian Science Foundation (grant No. 22-15-00454).
Author contribution: Eldarov CM — sample preparation, conducting HPLC-MS/MS, chromatography–mass spectrometry data processing, manuscript writing and editing; Starodubtseva NL — metabolomic data analysis, statistical analysis; manuscript writing and editing; Shevtsova YuA — conducting the model experiment, sample acquisition and characterization, discussing the results, manuscript writing and editing; Goryunov KV — conducting the model experiment, sample acquisition and characterization, manuscript writing and editing; Ionov OV — study planning, manuscript editing; Silachev DN — study planning, discussing the results, manuscript writing and editing.
Compliance with ethical standards: the study was approved by the Ethics Committee of the Belozersky Institute Of Physico-Chemical Biology, Moscow State University (protocol No. 8/22 dated 12 June 2022). The study was compliant with the standards of the Ethics Committee of the Belozersky Institute Of Physico- Chemical Biology, Moscow State University, and the Declaration of Helsinki (1964).