ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
Copyright: © 2024 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
ORIGINAL RESEARCH
Estimation of the impact of chronic radiation exposure on telomere loss in women’s T lymphocytes
About authors
Urals Research Center for Radiation Medicine of the Federal Medical Biological Agency, Chelyabinsk, Russia
Correspondence should be addressed: Yana V. Krivoshchapova
Vorovsky, 68А, Chelyabinsk, 454141, Russia; ur.liam@oh_anaY
About paper
Funding: State Assignment of FMBA of Russia, R&D project “Long-term Cytogenetic Effects of Chronic Exposure in Residents of the Southern Urals.
Acknowledgements: the author would like to express sincere gratitude to Yu.R. Akhmadullina, acting head of the Laboratory of Radiation Genetics, for valuable comments.
Compliance with ethical standards: the study was approved by the Ethics Committee of the Urals Research Center for Radiation Medicine (protocol No. 8 dated 19 June 2024). Individuals, who were included into the cytogenetic study, gave the informed consent to blood sampling and further assessment. All forms and questionnaires are stored in the Laboratory of Radiation Genetics of the Urals Research Center for Radiation Medicine.
Received: 2024-10-16
Accepted: 2024-11-13
Published online: 2024-12-13
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Fig. 1. Example of finding telomere loss in the red-blue filter and inverted image. All four telomeres are visible in the left cnromosome. An example of telomere loss in one q arm chromatid is provided on the right
Fig. 2. Example of finding chromosome telomere loss in the red-blue filter and inverted image. No telomeres can be seen in both q arms
Fig. 3. Baseline data by dose groups
Fig. 4. Rate of chromatid and chromosome telomere loss observations in various exposed groups
Fig. 5. Median, 5th and 95th percentiles, minima and maxima of baseline data for different exposure groups
Table 1. Characteristics of examined women
Table 2. Median (5% and 95%) telomere loss in T-lymphocytes of exposed women of the Southern Urals
