ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
Copyright: © 2025 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
ORIGINAL RESEARCH
Oxidative protein destruction products as markers of chronic kidney disease progression in diabetes mellitus
About authors
1 South Ural State Medical University, Chelyabinsk, Russia
2 Chelyabinsk Regional Clinical Hospital, Chelyabinsk, Russia
3 Patrice Lumumba Peoples' Friendship University of Russia, Moscow, Russia
Correspondence should be addressed: Lyudmila Yu. Zhuravleva
Vorovsky, 70 (Medgorodok), str. 8, 454048, Chelyabinsk, Russia; ur.liam@0161_analim
About paper
Author contribution: Osikov MV, Efros LA — study planning, developing the study concept and design, literature review, data interpretation, manuscript draft writing; Zhuravleva LYu — data acquisition, statistical processing, data interpretation, manuscript draft writing; Fedosov AA — literature review, data interpretation, manuscript draft writing.
Compliance with ethical standards: the study was approved by the Ethics Committee of the South Ural State Medical University (protocol No. 5 dated 10 June 2024).
Received: 2025-01-27
Accepted: 2025-02-15
Published online: 2025-02-26
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Table 1. Estimated glomerular filtration rate in T1DM patients with CKD, ml/min/1.73 m2 (Ме [Q1; Q3])
Table 2. Blood plasma POM and TAC indicators, T1DM patients with CKD (Ме [Q1; Q3])
Note: the table gives total (S) POM products content values, spontaneous and metal-induced modes; ADNPH — aldehyde-dinitrophenylhydrozone; KDNPH — ketonedinitrophenylhydrozone; S uv — the level of carbonyl derivatives measured in the UV spectrum; S vl — the level of carbonyl derivatives measured in the visible light spectrum; RAP — reserve adaptive potential.
Table 3. Correlation between eGFR (ml/min/1.73 m2) and POM, LPP, and TAC, T1DM patients with CKD
Note: the table gives the Spearman's rank correlation coefficient (R) values; the statistically significant connections are highlighted in bold (p < 0.05).
