2025 / 01

Next Paper
DOI: 10.24075/brsmu.2025.011
Copyright: © 2025 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).

ORIGINAL RESEARCH

Oxidative protein destruction products as markers of chronic kidney disease progression in diabetes mellitus

Osikov MV1,2, Efros LA1,2, Zhuravleva LYu1,2, Fedosov AA3
About authors

1 South Ural State Medical University, Chelyabinsk, Russia

2 Chelyabinsk Regional Clinical Hospital, Chelyabinsk, Russia

3 Patrice Lumumba Peoples' Friendship University of Russia, Moscow, Russia

Correspondence should be addressed: Lyudmila Yu. Zhuravleva
Vorovsky, 70 (Medgorodok), str. 8, 454048, Chelyabinsk, Russia; ur.liam@0161_analim

About paper

Author contribution: Osikov MV, Efros LA — study planning, developing the study concept and design, literature review, data interpretation, manuscript draft writing; Zhuravleva LYu — data acquisition, statistical processing, data interpretation, manuscript draft writing; Fedosov AA — literature review, data interpretation, manuscript draft writing.

Compliance with ethical standards: the study was approved by the Ethics Committee of the South Ural State Medical University (protocol No. 5 dated 10 June 2024).

Received: 2025-01-27 Accepted: 2025-02-15 Published online: 2025-02-26
|
  1. Saharnyj diabet 2 tipa u vzroslyh: klinicheskie rekomendacii. Rubrikator klinicheskih rekomendacij. 2022 [data dostupa: 2025 janvar' 26]. Dostupna po ssylke: https://cr.minzdrav.gov.ru/schema/290_2.
  2. Dedov II, Shestakova MV, Vikulova OK, Zheleznjakova AV, Isakov MA, Sazonova DV, i dr. Saharnyj diabet v Rossijskoj Federacii: dinamika jepidemiologicheskih pokazatelej po dannym Federal'nogo registra saharnogo diabeta za period 2010–2022 gg. Saharnyj diabet. 2023; 26 (2): 104–23. DOI:10.14341/DM13035. Russian.
  3. Radia MMK. From pre-diabetes to diabetes: Diagnosis, treatments and translational research. Medicina (Kaunas). 2019; 55 (9): 546. DOI:10.3390/medicina55090546.
  4. Kidney Disease: Improving Global Outcomes (KDIGO) Diabetes Work Group. KDIGO 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease. Kidney Int. 2022; 102 (5S): S1–S127. DOI: 10.1016/j.kint.2022.06.008.
  5. Vikulova OK, Elfimova AR, Zheleznjakova AV, Isakov MA, Shamhalova MSh, Shestakova MV, i dr. Kal'kuljator riska razvitija hronicheskoj bolezni pochek: novye vozmozhnosti prognozirovanija patologii u pacientov s saharnym diabetom. Consilium Medicum. 2022; 24 (4): 224–33. DOI:10.26442/20751753.2022.4.201684. Russian.
  6. Dedov II, Shestakova MV, Vikulova OK, Zheleznjakova AV, Isakov MA. Jepidemiologicheskie harakteristiki saharnogo diabeta v Rossijskoj Federacii: kliniko-statisticheskij analiz po dannym registra saharnogo diabeta na 01.01.2021. Saharnyj diabet. 2021; 24 (3): 204–2. DOI: 10.14341/DM12759. Russian.
  7. Perkins BA, Bebu I, de Boer IH, Molitch M, Tamborlane W, Lorenzi G, et al. Risk Factors for Kidney Disease in Type 1 Diabetes. Diabetes Care. 2019; 42 (5): 883–90. Available from: https://doi.org/10.2337/dc18-2062.
  8. Patidar K, Deng JH, Mitchell CS, Ford Versypt AN. Cross-Domain Text Mining of Pathophysiological Processes Associated with Diabetic Kidney Disease. Int J Mol Sci. 2024; 25 (8): 4503. DOI: 10.3390/ijms25084503.
  9. Shutov AM. Hronicheskaja bolezn' pochek. Obshherossijskaja obshhestvennaja organizacija «Rossijskoe nauchnoe medicinskoe obshhestvo terapevtov» [Jelektronnyj resurs]. 2022 [data dostupa: 2025 janvar' 26]. Dostupno po ssylke: https://www.rnmot.ru/public/uploads/RNMOT/clinical/2022/Shutov_MR%20HBP%20dlja%20terapevtov.pdf. Russian.
  10. Tsuchida-Nishiwaki M, Uchida HA, Takeuchi H, Nishiwaki N, Maeshima Y, Saito C, et al. Association of blood pressure and renal outcome in patients with chronic kidney disease; a post hoc analysis of FROM-J study. Sci Rep. 2021; 11 (1): 14990. DOI: 10.1038/s41598-021-94467-z.
  11. Varkevisser RDM, Mul D, Aanstoot HJ, Wolffenbuttel BHR, van der Klauw MM. Differences in lipid and blood pressure measurements between individuals with type 1 diabetes and the general population: a cross-sectional study. BMJ Open. 2023; 13 (10): 073690. DOI: 10.1136/bmjopen-2023-073690.
  12. Eckardt KU, Delgado C, Heerspink HJL, Pecoits-Filho R, Ricardo AC., Stengel B, et al. Trends and perspectives for improving quality of chronic kidney disease care: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int. 2023; 104 (5): 888–903 DOI: 10.1016/j.kint.2023.05.013.
  13. Siligato R, Gembillo G, Cernaro V, Torre F, Salvo A, Granese R, et al. Maternal and Fetal Outcomes of Pregnancy in Nephrotic Syndrome Due to Primary Glomerulonephritis. Front Med (Lausanne). 2020; 7: 563094. DOI: 10.3389/fmed.2020.563094.
  14. Vyas DA, Eisenstein LG, Jones DS. Hidden in Plain Sight - Reconsidering the Use of Race Correction in Clinical Algorithms. N Engl J Med. 2020; 383 (9): 874–82. DOI: 10.1056/NEJMms2004740.
  15. Jha R, Lopez-Trevino S, Kankanamalage HR, Jha JC. Diabetes and Renal Complications: An Overview on Pathophysiology, Biomarkers and Therapeutic Interventions. Biomedicines. 2024; 12 (5): 1098. DOI: 10.3390/biomedicines12051098.
  16. Saharnyj diabet 1 tipa u vzroslyh: klinicheskie rekomendacii. Rubrikator klinicheskih rekomendacij. 2022 [data dostupa: 2025 janvar' 26]. Dostupno po ssylke: https://cr.minzdrav.gov.ru/schema/286_2. Russian.
  17. Hronicheskaja bolezn' pochek (HBP): klinicheskie rekomendacii. Rubrikator klinicheskih rekomendacij. 2021 [data dostupa: 2025 janvar' 26]. Dostupno po ssylke: https://cr.minzdrav.gov.ru/schema/469_2. Russian.
  18. Wallander M, Axelsson KF, Nilsson AG, Lundh D, Lorentzon M. Type 2 Diabetes and Risk of Hip Fractures and Non-Skeletal Fall Injuries in the Elderly: A Study From the Fractures and Fall Injuries in the Elderly Cohort (FRAILCO). J Bone Miner Res. 2017; 32 (3): 449–60. Available from: https://doi.org/10.1002/jbmr.3002.
  19. Fomina MA, Wallander M, Axelsson KF, Nilsson AG, Lundh D, Lorentzon M. Type 2 Diabetes and Risk of Hip Fractures and Non-Skeletal Fall Injuries in the Elderly: A Study From the Fractures and Fall Injuries in the Elderly Cohort (FRAILCO). J Bone Miner Res. 2017; 32 (3): 449–60. DOI: 10.1002/jbmr.3002.
  20. Tonneijck L, Muskiet MH, Smits MM, van Bommel EJ, Heerspink HJ, van Raalte DH, Joles JA. Glomerular Hyperfiltration in Diabetes: Mechanisms, Clinical Significance, and Treatment. J Am Soc Nephrol. 2017; 28 (4): 1023–39. DOI: 10.1681/ASN.2016060666.
  21. Kanbay M, Copur S, Guldan M, Ozbek L, Hatipoglu A, Covic A, Mallamaci F, Zoccali C. Proximal tubule hypertrophy and hyperfunction: a novel pathophysiological feature in disease states. Clin Kidney J. 2024; 17 (7): 195. DOI: 10.1093/ckj/sfae195.
  22. Jin L, Wang X, Liu Y, Xiang Q, Huang R. High levels of blood glycemic indicators are associated with chronic kidney disease prevalence in non-diabetic adults: Cross-sectional data from the national health and nutrition examination survey 2005–2016. J Clin Transl Endocrinol. 2024; 36: 100347. DOI: 10.1016/j.jcte.2024.100347.
  23. Kanbay M, Copur S, Bakir CN, Covic A, Ortiz A, Tuttle KR. Glomerular hyperfiltration as a therapeutic target for CKD. Nephrol Dial Transplant. 2024; 39 (8): 1228–38. DOI: 10.1093/ndt/gfae027.
  24. Jung CY, Yoo TH. Pathophysiologic Mechanisms and Potential Biomarkers in Diabetic Kidney Disease. Diabetes Metab J. 2022; 46 (2): 181–97. DOI: 10.4093/dmj.2021.0329.
  25. Hassan HA, Ahmed HS, Hassan DF. Free radicals and oxidative stress: Mechanisms and therapeutic targets: Review article. Hum Antibodies. 2024; 3. DOI: 10.3233/HAB-240011.
  26. Wang N, Zhang C. Oxidative Stress: A Culprit in the Progression of Diabetic Kidney Disease. Antioxidants (Basel). 2024; 13 (4): 455. DOI: 10.3390/antiox13040455.
  27. Król-Kulikowska M, Banasik M, Kepinska M. The Effect of Selected Nitric Oxide Synthase Polymorphisms on the Risk of Developing Diabetic Nephropathy. Antioxidants (Basel). 2024; 13(7): 838. DOI:10.3390/antiox13070838.
  28. Wang H, Ba Y, Xing Q, Du JL. Diabetes mellitus and the risk of fractures at specific sites: a meta-analysis. BMJ Open. 2019; 9 (1): 024067. DOI: 10.1136/bmjopen-2018-024067.
  29. Zhao DM, Zhong R, Wang XT, Yan ZH. Mitochondrial dysfunction in diabetic nephropathy: insights and therapeutic avenues from traditional Chinese medicine. Front Endocrinol (Lausanne). 2024; 15: 1429420. DOI: 10.3389/fendo.2024.1429420.
  30. Mazzieri A, Porcellati F, Timio F, Reboldi G. Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection. Int J Mol Sci. 2024; 25 (7): 3969. DOI: 10.3390/ijms25073969.
  31. Lin W, Shen P, Song Y, Huang Y, Tu S. Reactive Oxygen Species in Autoimmune Cells: Function, Differentiation, and Metabolism. Front Immunol. 2021; 12: 635021. Available from: https://doi.org/10.3389/fimmu.2021.635021.
  32. Vodošek Hojs N, Bevc S, Ekart R, Hojs R. Oxidative Stress Markers in Chronic Kidney Disease with Emphasis on Diabetic Nephropathy. Antioxidants (Basel). 2020; 9 (10): 925. Available from: https://doi.org/10.3390/antiox9100925.
  33. Zhang P, Li T, Wu X, Nice EC, Huang C, Zhang Y. Oxidative stress and diabetes: antioxidative strategies. Front Med. 2020; 14 (5): 583‒600. DOI: 10.1007/s11684-019-0729-1.
  34. Daenen K, Andries A, Mekahli D, et al. Okislitel'nyj stress pri hronicheskoj bolezni pochek. Pediatr Nephrol. 2019; 34: 975–91. Available from: https://doi.org/10.1007/s00467-018-4005-4.
  35. Smith A, et al. Molecular mechanisms of oxidative stress in pathologies. Journal of Molecular Biology. 2022; 20 (3).
  36. Johnson B, et al. Therapeutic approaches targeting antioxidant imbalance. Medical Research Reviews. 2023; 25 (1).
  37. Cejlikman V. E. O vlijanii okislitel'nogo stressa na organizm cheloveka. Mezhdunarodnyj nauchnyj zhurnal. 2022; 3 (117). Dostupno po ssylke: https://research-journal.org/archive/3-117-2022-march/vliyanie-okislitelnogo-stressa-na-organizm-cheloveka (data obrashhenija: 16.02.2025). DOI: 10.23670/IRJ.2022.117.3.037.
  38. Lju Dzh, Chen S, Bisvas S, Nagrani N, Chu Ju, Chakrabarti S, i dr. Okislitel'nyj stress, vyzvannyj gljukozoj, i uskorennoe starenie jendotelial'nyh kletok oposredovany istoshheniem mitohondrial'nyh SIRTs. Physiol Rep. 2020; 8: e14331. DOI: 10.14814/phy2.143312020.
  39. Wang C, et al. Reactive oxygen species and their role in cellular signaling. Nature Reviews Molecular Cell Biology. 2021; 18 (5).
  40. Walle M, Whittier DE, Frost M, Müller R, Collins CJ. Meta-analysis of Diabetes Mellitus-Associated Differences in Bone Structure Assessed by High-Resolution Peripheral Quantitative Computed Tomography. Curr Osteoporos Rep. 2022; 20 (6): 398–409. DOI: 10.1007/s11914-022-00755-6.
  41. Darenskaya M, Kolesnikov S, Semenova N, Kolesnikova L. Diabetic Nephropathy: Significance of Determining Oxidative Stress and Opportunities for Antioxidant Therapies. Int J Mol Sci. 2023; 24 (15): 12378. DOI: 10.3390/ijms241512378.