ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
Copyright: © 2025 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
ORIGINAL RESEARCH
Assessing proliferative activity and glucose metabolism in cells of salivary gland mucoepidermoid carcinoma using different grading systems
About authors
1 Patrice Lumumba Peoples' Friendship University of Russia, Moscow, Russia
2 National Medical Research Center of Dentistry and Maxillofacial Surgery, Moscow, Russia
Correspondence should be addressed: Diana Rosina Familia Frias
Mikluho-Maklaya, 21, bld. 2, Moscow, 117198, Russia; moc.liamg@62ffrd
About paper
Author contribution: Babichenko II — study concept and design; Familia Frias DR, Tigay YuO, Visaitova ZYu — data acquisition and processing; Familia Frias DR — manuscript writing; Babichenko II, Ivina AA — editing.
Compliance with ethical standards: the study was approved by the Ehics Committee of RUDN (protocol No. 3 dated 11 March 2025).
Received: 2025-03-13
Accepted: 2025-03-27
Published online: 2025-04-11
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Fig. 1. MEC, hematoxylin and eosin stain ×100 (A). Immunohistochemical reaction with antibody against Ki-67 ×200 (B). GLUT1 cytoplasm staining in epidermoid and intermediate cells, weak response in mucin-producing cells ×100 (C). High proliferative activity based on Ki-67 in epidermoid cells ×400 (D). Intense GLUT1 cytoplasmic membrane staining in epidermoid cells ×200 (E). IHC reaction with the background Mayer's hematoxylin DAB stain
Table 1. Mucoepidermoid carcinoma grading systems
Note: n/a — not applicable.
Table 2. Pairwise comparison (Dunn–Bonferroni test)
Table 3. Correlation between GLUT1 and Ki-67 and tumor grades
