2025 / 02

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DOI: 10.24075/brsmu.2025.017
Copyright: © 2025 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).

ORIGINAL RESEARCH

Assessing proliferative activity and glucose metabolism in cells of salivary gland mucoepidermoid carcinoma using different grading systems

Familia Frias DR1, Visaitova ZYu2, Tigay YuO1, Ivina AA1, Babichenko II1,2
About authors

1 Patrice Lumumba Peoples' Friendship University of Russia, Moscow, Russia

2 National Medical Research Center of Dentistry and Maxillofacial Surgery, Moscow, Russia

Correspondence should be addressed: Diana Rosina Familia Frias
Mikluho-Maklaya, 21, bld. 2, Moscow, 117198, Russia; moc.liamg@62ffrd

About paper

Author contribution: Babichenko II — study concept and design; Familia Frias DR, Tigay YuO, Visaitova ZYu — data acquisition and processing; Familia Frias DR — manuscript writing; Babichenko II, Ivina AA — editing.

Compliance with ethical standards: the study was approved by the Ehics Committee of RUDN (protocol No. 3 dated 11 March 2025).

Received: 2025-03-13 Accepted: 2025-03-27 Published online: 2025-04-11
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  1. Peraza A, Gómez R, Beltran J, Amarista FJ. Mucoepidermoid carcinoma. An update and review of the literature. J Stomatol Oral Maxillofac Surg. 2020; 121: 713–20.
  2. Ullah A, Khan J, Waheed A, et al. Mucoepidermoid Carcinoma of the Salivary Gland: Demographics and Comparative Analysis in U.S. Children and Adults with Future Perspective of Management. Cancers (Basel). 2022; 15 (1): 250. Published 2022. DOI: 10.3390/cancers15010250.
  3. Robinson L, van Heerden MB, Ker-Fox JG, Hunter KD, van Heerden WFP. Expression of Mucins in Salivary Gland Mucoepidermoid Carcinoma. Head Neck Pathol. 2021; 15 (2): 491–502. DOI: 10.1007/s12105-020-01226-z.
  4. El-Naggar AK, Chan JKC, Rubin-Grandis J, Takata T, Slootweg PJ, International Agency for Research on Cancer. World Health Organization classification of tumours. 4th ed. Lyon: International Agency for Research on Cancer, 2017.
  5. Donempudi P, Bhayya H, Venkateswarlu M, Avinash Tejasvi M L, Paramkusam G. Mucoepidermoid carcinoma of the minor salivary gland: Presenting as ranula. J Can Res Ther. 2018; 14: 1418–21.
  6. Fehr A, Werenicz S, Trocchi P et al. Mucoepidermoid carcinoma of the salivary glands revisited with special reference to histologic grading and CRTC1/3-MAML2 genotyping. Virchows Arch (2021). Available from: https://doi.org/10.1007/s00428-021-03146-x.
  7. Lin HH, Limesand KH, Ann DK. Current State of Knowledge on Salivary Gland Cancers. Crit Rev Oncog. 2018; 23 (3–4): 139–51. DOI: 10.1615/CritRevOncog.2018027598.
  8. Gotoh S, Nakasone T, Matayoshi A, et al. Mucoepidermoid carcinoma of the anterior lingual salivary gland: A rare case report. Mol Clin Oncol. 2022; 16 (1): 7. DOI: 10.3892/mco.2021.2444.
  9. Cipriani NA, Lusardi JJ, McElherne J, Pearson AT, Olivas AD, Fitzpatrick C, et al. Mucoepidermoid carcinoma: A comparison of histologic grading systems and relationship to MAML2 rearrangement and prognosis. Am J Surg Pathol. 2019; 43: 885–97.
  10. Qannam A, Bello IO. Comparison of histological grading methods in mucoepidermoid carcinoma of minor salivary glands. Indian J Pathol Microbiol. 2016; 59: 457–62. DOI: 10.4103/0377-4929.191765.
  11. Sampedro-Núñez M, Bouthelier A, Serrano-Somavilla A, et al. LAT-1 and GLUT1 Carrier Expression and Its Prognostic Value in Gastroenteropancreatic Neuroendocrine Tumors. Cancers (Basel). 2020; 12 (10): 2968. Available from: https://doi.10.3390/cancers12102968.
  12. Yang H, Zhong JT, Zhou SH, Han HM. Roles of GLUT1 and HKII expression in the biological behavior of head and neck cancer. Oncotarget. 2019; 10 (32): 3066–83. DOI: 10.18632/oncotarget.24684.
  13. Kang F, Ma W, Ma X, et al. Propranolol inhibits glucose metabolism and 18F-FDG uptake of breast cancer through posttranscriptional downregulation of hexokinase-2. J Nucl Med. 2014; 55 (3): 439– 45. DOI: 10.2967/jnumed.113.121327.
  14. Kaza S, Rao TJM, Mikkilineni A, Ratnam GV, Rao DR. Ki-67 Index in Salivary Gland Neoplasms. Int J Phonosurg Laryngol. 2016; 6 (1): 1–7.
  15. de Souza LB, de Oliveira LC, Nonaka CFW, et al. Immunoexpression of GLUT1 and angiogenic index in pleomorphic adenomas, adenoid cystic carcinomas, and mucoepidermoid carcinomas of the salivary glands. Eur Arch Otorhinolaryngol. 2017; 274: 2549– 56. Available from: https://doi.org/10.1007/s00405-017-4530-y.
  16. Demasi APD, Costa AF, Altemani A, Furuse C, Araújo NS and Araújo VC. Glucose transporter protein 1 expression in mucoepidermoid carcinoma of salivary gland: correlation with grade of malignancy. International Journal of Experimental Pathology. 2010; 91: 107–13. Available from: https://doi.org/10.1111/j.1365-2613.2009.00702.x.
  17. Skalova A, Lehtonen H, von Boguslawsky K, Leivo I. Prognostic significance of cell proliferation in mucoepidermoid carcinomas of the salivary gland: clinicopathological study using MIB 1 antibody in paraffin sections. Hum Pathol. 1994; 25 (9): 929–35. DOI: 10.1016/0046-8177(94)90014-0.