ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
Copyright: © 2025 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
ORIGINAL RESEARCH
Efficacy of using melatonin per rectum for experimental acute cerebral ischemia
About authors
1 South Ural State Medical University, Chelyabinsk, Russia
2 Chelyabinsk Regional Clinical Hospital, Chelyabinsk, Russia
3 Chelyabinsk Regional Clinical Therapeutic Hospital for War Veterans, Chelyabinsk, Russia
4 Peoples' Friendship University of Russia, Moscow, Russia
Correspondence should be addressed: Alexey V. Shelomentsev
Vorovskogo, 64, Chelyabinsk, 454092, Russia; ur.liam@81weznemolehcsva
About paper
Author contribution: Osikov MV — study concept and design, manuscript editing and approval; Shelomentsev AV — data acquisition, literature review, analysis and interpretation of the results; Boyko MS — statistical analysis; Shishkova YuS, Fedosov AA — manuscript editing.
Compliance with ethical standards: the study was approved by the Ethics Committee of the South Ural State Medical University (protocol No. 5 dated 10 June 2024). Animals were kept and handled in accordance with the ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines and animal handling principles based on the provisions of the Declaration of Helsinki and the guidelines contained in the EU Council Directive 86/609/ECC and the European Convention for the protection of vertebrate animals used for experimental and other scientific purposes.
Received: 2025-06-24
Accepted: 2025-07-21
Published online: 2025-07-26
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Table 1. Effect of MT on neurological status in EACI (Ме [Q1; Q3])
Note: significant differences based on the Mann–Whitney U-test are designated as follows: * — compared to group 1 (p < 0.05); # — compared to group 2 (p < 0.05); & — significant differences based on the Wilcoxon test between days 3 and 7 within the same group (p < 0.05).
Table 2. Effect of MT on microcirculation values in EACI (Ме [Q1; Q3])
Note: significant differences based on the Mann–Whitney U-test are designated as follows: * — compared to group 1 (p < 0.05); # — compared to group 2 (p < 0.05); & — significant differences based on the Wilcoxon test between days 3 and 7 within the same group (p < 0.05).
Table 3. Correlation between neurological status indicators and MR in EACI in the context of using MT-based rectal suppositories
Note: r — Spearman’s rank correlation coefficient (r < 0.05).
