2025 / 04

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DOI: 10.24075/brsmu.2025.035
Copyright: © 2025 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).

ORIGINAL RESEARCH

Efficacy of using melatonin per rectum for experimental acute cerebral ischemia

Osikov MV1,2, Shelomentsev AV1,3, Boyko MS1, Shishkova YuS1, Fedosov AA4
About authors

1 South Ural State Medical University, Chelyabinsk, Russia

2 Chelyabinsk Regional Clinical Hospital, Chelyabinsk, Russia

3 Chelyabinsk Regional Clinical Therapeutic Hospital for War Veterans, Chelyabinsk, Russia

4 Peoples' Friendship University of Russia, Moscow, Russia

Correspondence should be addressed: Alexey V. Shelomentsev
Vorovskogo, 64, Chelyabinsk, 454092, Russia; ur.liam@81weznemolehcsva

About paper

Author contribution: Osikov MV — study concept and design, manuscript editing and approval; Shelomentsev AV — data acquisition, literature review, analysis and interpretation of the results; Boyko MS — statistical analysis; Shishkova YuS, Fedosov AA — manuscript editing.

Compliance with ethical standards: the study was approved by the Ethics Committee of the South Ural State Medical University (protocol No. 5 dated 10 June 2024). Animals were kept and handled in accordance with the ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines and animal handling principles based on the provisions of the Declaration of Helsinki and the guidelines contained in the EU Council Directive 86/609/ECC and the European Convention for the protection of vertebrate animals used for experimental and other scientific purposes.

Received: 2025-06-24 Accepted: 2025-07-21 Published online: 2025-07-26
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