2025 / 05

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DOI: 10.24075/brsmu.2025.044
Copyright: © 2025 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).

ORIGINAL RESEARCH

Cytocompatibility of pressureless sintered porous B4C-ceramics assessed in vitro

Chepeleva EV, Kozyr KV, Vaver AA, Khakhalkin VV
About authors

Institute of Experimental Biology and Medicine, Meshalkin National Medical Research Center, Novosibirsk, Russia

Correspondence should be addressed: Elena V. Chepeleva
Rechkunovskaya, 15, Novosibirsk, 630055, Russia; ur.niklahsem@avelepehc_e, ur.liam@azerama

About paper

Funding: the study was supported by the Russian Science Foundation grant (project No. 25-25-00187).

Author contribution: Chepeleva EV, Khakhalkin VV — study concept and design; Chepeleva EV, Kozyr KV, Vaver AA, Khakhalkin VV — experimental procedure and data processing; Chepeleva EV — manuscript writing; Kozyr KV, Vaver AA, Khakhalkin VV — manuscript editing.

Received: 2025-09-10 Accepted: 2025-09-28 Published online: 2025-10-12
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Fig. 1. Overall appearance of the B4C ceramics samples produced by pressureless sintering
Fig. 2. Microstructure of the surface of the B4C ceramics produced by pressureless sintering. Scale bar — 70 µm
Fig. 3. AFM image of the relief of the surface of the B4C ceramics produced by pressureless sintering. Field size 10 × 10 µm. Scale of the Z axis: 0–0.74 µm
Fig. 4. Viability of the MSC-DP-1 mesenchymal stem cells after culturing for 24 and 72 h with the extracts obtained from the boron carbide (B4C) and titanium (Ti) samples sterilized by autoclaving (А) or with ethylene oxide (Е). Ме (25%; 75%), Mann–Whitney U-test
Table 1. Comparative analysis of the major classes of materials for bone grafting [3–11]
Table 2. Characteristics of the B4C ceramics samples produced by pressureless sintering [18]