ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
Copyright: © 2025 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
ORIGINAL RESEARCH
Expression of microRNA miR146a in the blood plasma of rats with obesity and knee arthrosis after administration of dexamethasone
About authors
1 Federal State Budgetary Educational Institution of Higher Education “LSMU named St. Luke”, Russia
2 Non-governmental private institusion Scientific Diagnostic Center "Policlinic on Smolenskaya"
Correspondence should be addressed: Aleksey S. Ivanov
A. Dikogo, 16A, kv. 73, 111396, Moskva, Rossiya: ur.liam@5891golotamvartahsas
About paper
Author contribution: Ivanov AS — study design development, experimental design; Tananakina TP — study design development, participation in the experimental design, and scientific supervision; Kashchenko SA — scientific editing, scientific supervision, and participation in the experimental design; Pogorelova IA — technical proofreading, participation in the experimental design.
Compliance with ethical standards: the study was approved by the Ethics Committee of the St. Luke's Lugansk State Medical University of the Russian Ministry of Health (protocol No 1 dated 23 September 2025). When working with laboratory animals, the conditions of care and experimentation were fully compliant with the standards of Order No. 199n of the Russian Ministry of Health "On Approval of the Rules of Good Laboratory Practice" 1, adhering to the principles of the European Convention for the Protection of Vertebrate Animals used for Experimental and other Scientific Purposes, and strictly adhering to the Directive of the European Parliament and of the Council of the European Union on the Protection of Animals used for Scientific Purposes.
Received: 2025-10-04
Accepted: 2025-10-30
Published online: 2025-11-11
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Fig. Dynamics of changes in the miR146a parameter in blood plasma of rats in groups 1, 2, 3, 4, and 5 on Days 3, 5 and 10
Table 1. Dynamics of serum miR146a expression in rats in groups 1, 2, and 3 on days 3, 5, and 10
Note: р — the root mean square error at a value level of 0.05.
Table 2. Dynamics of miR146a expression in rat serum in groups 1, 2, and 4 on Days 3, 5, and 10
Note: р — the root mean square error at a value level of 0.05.
Table 3. Dynamics of miR146a expression indicators in rat serum in groups 1, 2, and 5 on Days 3, 5, and 10
Note: р — the root mean square error at a value level of 0.05.
