Funding: the study was supported by a grant from the Russian Science Foundation (project No. 25-25-20072) and the Ministry of Education and Science of the Kursk Region (agreement No. 241 dated May 19, 2025).

Author contribution: Semikina EV — genotyping of DNA samples, analysis of obtained data, writing of the text; Azarova YuE — concept and design of the study, fundraising, collection and processing of materials, writing of the text; Panichev SA — genotyping of DNA samples, entering genotyping results into the database; Basareva OI — selection of functionally significant polymorphic variants of the OGG1 gene, selection of primers and probes for SNP genotyping; Dzhanchatova NV — genotyping of DNA samples; Alferova EYu — sample preparation: DNA extraction from blood, measurement of concentration and purity of DNA samples; Polonikov AV — analyzed the data, reviewed the literature, and made final edits. The authors approved the version for publication and agreed to be accountable for all aspects of the work, ensuring that any questions related to the accuracy and integrity of any part of it are properly reviewed and resolved.

Compliance with ethical standards: the study was approved by the Regional Ethics Committee at Kursk State Medical University (meeting minutes No. 1 dated January 20, 2025).