Copyright: © 2026 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).

ORIGINAL RESEARCH

Linguo-semantic descriptors of painful sensations as a mirror therapy effectiveness criterion in trauma-related amputation

Petrash EA1 , Nikishina VB1 , Yunina-Pakulova NYu1 , Minaev AS1 , Melkonyan GG2 , Lytkina KA2 , Karpenko AS3
About authors

1 Pirogov Russian National Research Medical University, Moscow, Russia

2 Hospital for War Veterans No. 3 of the Moscow City Department of Health, Moscow, Russia

3 Moscow State Institute of International Relations (University) of the Ministry of Foreign Affairs of the Russian Federation, Moscow, Russia

Correspondence should be addressed: Ekaterina A. Petrash
Ostrovityanova, 1, Moscow, 117997, Russia; ur.liam@hsartep

About paper

Author contribution: equivalent.

Compliance with ethical standards: the study approved by the Ethics Committee of the Pirogov University (protocol No. 249 dated 17 March 2025) was compliant with the requirements of the Fundamentals of Legislation "On the Protection of Citizens' Health”; all subjects submitted the informed consent for assessment.

Received: 2026-01-29 Accepted: 2026-02-19 Published online: 2026-02-26
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  1. Morgan L., Aldington D. Comorbid chronic pain and post-traumatic stress disorder in UK veterans: a lot of theory but not enough evidence. Br J Pain, 2020.
  2. Resnik L, Ekerholm S, Borgia M, Clark MA. A national study of Veterans with major upper limb amputation: Survey methods, participants, and summary findings. 2019.
  3. Wu H, Saini C, Medina R, Hsieh SL, Meshkati A, Sung K. Pain without presence: a narrative review of the pathophysiological landscape of phantom limb pain. Front Pain Res. 2025; 6: 1419762.
  4. Collins KL. A review of current theories and treatments for phantom limb pain. The Journal of Clinical Investigation. 2018; 128 (6): 2168–76.
  5. Kondratev IA, Dzhodzhua AV, Anankin AA, i dr. Sovremennye predstavleniya o fantomnoj boli i metodah eyo lecheniya. Vestnik nacional'nogo mediko-hirurgicheskogo centra im. N. I. Pirogova. 2025; 20 (3). Russian.
  6. Kuffler DP. Evolving techniques for reducing phantom limb pain. Exp Biol Med. 2023; 248 (7): 561–72.
  7. Andoh J, Milde C, Diers M, et al. Assessment of cortical reorganization and preserved function in phantom limb pain: a methodological perspective. Sci Rep. 2020.
  8. Florence SL, Hackett TA, Strata F. Thalamic and cortical contributions to neural plasticity after limb amputation. J Neurophysiol. 2000; 83 (5): 3154–9.
  9. Zhao P, Waxman SG, Hains BC. Sodium channel expression in the ventral posterolateral nucleus of the thalamus after peripheral nerve injury. Mol Pain. 2006.
  10. Kaas JH. The reorganization of somatosensory and motor cortex after peripheral nerve or spinal cord injury in primates. Prog Brain Res. 2000.
  11. Rasmusson DD. Reorganization of raccoon somatosensory cortex following removal of the fifth digit. J Comp Neurol. 1982.
  12. Makin TR, Flor H. Brain (re)organisation following amputation: Implications for phantom limb pain. NeuroImage. 2020.
  13. Ramachandran VS, Hirstein W. The perception of phantom limbs. The D. O. Hebb lecture. Brain: A Journal of Neurology. 1998.
  14. Katz J, Melzack R. Pain "memories" in phantom limbs: review and clinical observations. Pain. 1990.
  15. Maravita A, Iriki A. Tools for the body (schema). Trends in Cognitive Sciences. 2004.
  16. Anderson-Barnes VC, McAuliffe C, Swanberg KM, Tsao JW. Phantom limb pain — a phenomenon of proprioceptive memory? Med Hypotheses. 2009.
  17. Di Pino G, Piombino V, Carassiti M, Ortiz-Catalan M. Neurophysiological models of phantom limb pain: what can be learnt. Minerva Anestesiol. 2021.
  18. Giaxoglou K. The Language of Pain: Expression or Description? Journal of Greek Linguistics. 2009; 9.
  19. Chiyohara S, Furukawa JI, Noda T, Morimoto J, Imamizu H. Proprioceptive short-term memory in passive motor learning Sci Rep. 2023.
  20. Moseley LG. I can't find it! Distorted body image and tactile dysfunction in patients with chronic back pain. Pain. 2008.
  21. Bittar RG, Otero S, Carter H, Aziz TZ. Deep brain stimulation for phantom limb pain. Journal of Clinical Neuroscience. 2005.
  22. Giummarra MJ, Gibson SJ, Georgiou-Karistianis N, Bradshaw JL. Central mechanisms in phantom limb perception: The past, present and future. Brain Research Reviews. 2007.
  23. Nikishina VB, Bobyncev II, Petrash EA, Minyahina KA. Deskriptory intraceptivnyh oshchushchenij pri fantomno-bolevom sindrome u lyudej s amputaciej nizhnih konechnostej. Kurskij nauchno-prakticheskij vestnik «CHelovek i ego zdorov'e». 2015; 3: 133–39. Russian.
  24. Zhang K, Ding L, Wang X, et al. Mirror therapy reduces excessive variability of motor network in stroke patients: a randomized controlled trial. Eur J Phys Rehabil Med. 2025; 61: 184–94.
  25. Zhuang J, Lei X, Guo X, Ding L, Jia J. Motor and parietal cortex activity responses to mirror visual feedback in patients with subacute stroke: An EEG study. Clin Neurophysiol Pract. 2025; 10: 12–21.
  26. Xie H-M, Zhang K-X, Wang S, et al. Effectiveness of Mirror Therapy for Phantom Limb Pain: A Systematic Review and Metaanalysis. Arch Phys Med Rehabil. 2022; 103: 988–97.
  27. Sanabria-Mazo JP, Colomer-Carbonell A, Fernández-Vázquez Ó, et al. A systematic review of cognitive behavioral therapy-based interventions for comorbid chronic pain and clinically relevant psychological distress. Front Psychol. 2023.
  28. Bicego A, Delmal P, Ledoux D, et al. Self-Hypnosis for Phantom Limb Pain: A Multiple-Case Study. OBM Integrative and Complementary Medicine. 2022.
  29. Lendaro E, Van der Sluis CK, Hermansson L, et al. Extended reality used in the treatment of phantom limb pain: a multicenter, doubleblind, randomized controlled trial. PAIN. 2025; 166 (3): 571–86.
  30. Marshall Wilensky. Eye Movement Desensitization and Reprocessing (EMDR) as a Treatment for Phantom Limb Pain. British Columbia School of Professional Psychology. Vancouver, British Columbia, Canada. 2006.
  31. Deconinck FJA, Smorenburg ARP, Benham A, Ledebt A, Feltham MG, Savelsbergh GJP. Reflections on Mirror Therapy: A Systematic Review of the Effect of Mirror Visual Feedback on the Brain. Neurorehabilitation and Neural Repair. 2015; 29: 349–61.
  32. Zhang JJQ, Fong KNK, Welage N, Liu KPY. The Activation of the Mirror Neuron System during Action Observation and Action Execution with Mirror Visual Feedback in Stroke: A Systematic Review. Neural Plast. 2018; 2018: 2321045.
  33. Mokienko OA, Bobrov PD, Soloveva AA, Isaev MR, Kerechanin YaV, Ratnikova VYu, i dr. Nejrofiziologicheskie markery illyuzii, vyzvannoj zerkal'noj vizual'noj obratnoj svyaz'yu. Vestnik RGMU. 2025; 5: 91–99. DOI: 10.24075/vrgmu.2025.052. Russian.
  34. Nikishina VB, SHagina ED, YUnina-Pakulova NYu, Petrash EA. Metodicheskie rekomendacii po sposobu korrekcii fantomnyh bolej metodom zerkal'noj terapii «Zerkalo FaBo». Moskva, 2024; 45 s. Russian.
  35. Meltzoff AN, Moore MK. Explaining facial imitation: A theoretical model. Early Development and Parenting. 1997.